3cxb

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{{Seed}}
 
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[[Image:3cxb.png|left|200px]]
 
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==Crystal Structure of sifa and skip==
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The line below this paragraph, containing "STRUCTURE_3cxb", creates the "Structure Box" on the page.
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<StructureSection load='3cxb' size='340' side='right'caption='[[3cxb]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [https://pdbe.org/3cxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [https://www.ebi.ac.uk/pdbsum/3cxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxb ProSAT]</span></td></tr>
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{{STRUCTURE_3cxb| PDB=3cxb | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of sifa and skip===
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[https://www.uniprot.org/uniprot/SIFA_SALTY SIFA_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.<ref>PMID:12010459</ref> <ref>PMID:15905402</ref> <ref>PMID:18996344</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 18996344 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_18996344}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxb ConSurf].
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3CXB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation., Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI, Cell Host Microbe. 2008 Nov 13;4(5):434-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18996344 18996344]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Salmonella typhimurium]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Chai J]]
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[[Category: Complex]]
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[[Category: Huang Z]]
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[[Category: Cytoplasm]]
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[[Category: Membrane]]
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[[Category: Polymorphism]]
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[[Category: Sifa]]
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[[Category: Signaling protein]]
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[[Category: Skip]]
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[[Category: Virulence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 20:04:38 2009''
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Current revision

Crystal Structure of sifa and skip

PDB ID 3cxb

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