2jpe

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(New page: 200px<br /><applet load="2jpe" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jpe" /> '''FHA domain of NIPP1'''<br /> ==About this S...)
Current revision (10:10, 20 December 2023) (edit) (undo)
 
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[[Image:2jpe.jpg|left|200px]]<br /><applet load="2jpe" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2jpe" />
 
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'''FHA domain of NIPP1'''<br />
 
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==About this Structure==
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==FHA domain of NIPP1==
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2JPE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JPE OCA].
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<StructureSection load='2jpe' size='340' side='right'caption='[[2jpe]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jpe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JPE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jpe OCA], [https://pdbe.org/2jpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jpe RCSB], [https://www.ebi.ac.uk/pdbsum/2jpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jpe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PP1R8_MOUSE PP1R8_MOUSE] Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development.<ref>PMID:15501817</ref> <ref>PMID:15199142</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/2jpe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jpe ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Fujioka Y]]
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[[Category: Fujioka, Y.]]
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[[Category: Inagaki F]]
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[[Category: Inagaki, F.]]
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[[Category: Kikuchi K]]
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[[Category: Kikuchi, K.]]
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[[Category: Kumeta H]]
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[[Category: Kumeta, H.]]
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[[Category: Ogura K]]
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[[Category: Ogura, K.]]
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[[Category: Tanuma N]]
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[[Category: Tanuma, N.]]
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[[Category: fha domain]]
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[[Category: mrna splicing]]
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[[Category: nipp1]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 12:39:27 2007''
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Current revision

FHA domain of NIPP1

PDB ID 2jpe

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