2kd2

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{{Seed}}
 
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[[Image:2kd2.png|left|200px]]
 
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==NMR Structure of FAIM-CTD==
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The line below this paragraph, containing "STRUCTURE_2kd2", creates the "Structure Box" on the page.
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<StructureSection load='2kd2' size='340' side='right'caption='[[2kd2]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kd2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KD2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kd2 OCA], [https://pdbe.org/2kd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kd2 RCSB], [https://www.ebi.ac.uk/pdbsum/2kd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kd2 ProSAT]</span></td></tr>
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{{STRUCTURE_2kd2| PDB=2kd2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FAIM1_MOUSE FAIM1_MOUSE] Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.<ref>PMID:10075978</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kd2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kd2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fas apoptosis inhibitory molecule (FAIM) is a soluble cytosolic protein inhibitor of programmed cell death and is found in organisms throughout the animal kingdom. A short isoform of FAIM is expressed in all tissue types, while an alternatively spliced long isoform is specifically expressed in the brain. Here, the short isoform is shown to consist of two independently folding domains in contact with each other. The NMR solution structure of the C-terminal domain of murine FAIM is solved in isolation and revealed to be a novel protein fold, a noninterleaved seven-stranded beta-sandwich. The structure and sequence reveal several residues that are likely to be involved in functionally significant interactions with the N-terminal domain or other binding partners. Chemical shift perturbation is used to elucidate contacts made between the N-terminal domain and the C-terminal domain.
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===NMR Structure of FAIM-CTD===
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Fas Apoptosis Inhibitory Molecule Contains a Novel beta-Sandwich in Contact with a Partially Ordered Domain.,Hemond M, Rothstein TL, Wagner G J Mol Biol. 2009 Jan 13. PMID:19168072<ref>PMID:19168072</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19168072}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kd2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19168072 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19168072}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2KD2 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KD2 OCA].
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==Reference==
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<ref group="xtra">PMID:19168072</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hemond, M.]]
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[[Category: Hemond M]]
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[[Category: Wagner, G.]]
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[[Category: Wagner G]]
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[[Category: Apoptosis]]
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[[Category: Beta sandwich]]
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[[Category: Protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 10:56:01 2009''
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Current revision

NMR Structure of FAIM-CTD

PDB ID 2kd2

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