3fr5

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{{Seed}}
 
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[[Image:3fr5.jpg|left|200px]]
 
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==N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors==
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The line below this paragraph, containing "STRUCTURE_3fr5", creates the "Structure Box" on the page.
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<StructureSection load='3fr5' size='340' side='right'caption='[[3fr5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FR5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I4A:5-(3-CARBAMOYLBENZYL)-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-4-CARBOXYLIC+ACID'>I4A</scene></td></tr>
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{{STRUCTURE_3fr5| PDB=3fr5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fr5 OCA], [https://pdbe.org/3fr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fr5 RCSB], [https://www.ebi.ac.uk/pdbsum/3fr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fr5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/3fr5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fr5 ConSurf].
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<div style="clear:both"></div>
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===N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors===
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==See Also==
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*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_19217286}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 19217286 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19217286}}
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==About this Structure==
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3FR5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FR5 OCA].
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==Reference==
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<ref group="xtra">PMID:19217286</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Axen, E.]]
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[[Category: Large Structures]]
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[[Category: Barf, T.]]
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[[Category: Axen E]]
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[[Category: Haile, S.]]
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[[Category: Barf T]]
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[[Category: Hammer, K.]]
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[[Category: Haile S]]
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[[Category: Lehmann, F.]]
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[[Category: Hammer K]]
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[[Category: Medina, C.]]
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[[Category: Lehmann F]]
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[[Category: Rondahl, L.]]
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[[Category: Lundb ck T]]
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[[Category: Svensson, S.]]
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[[Category: Medina C]]
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[[Category: Uppenberg, J.]]
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[[Category: Rondahl L]]
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[[Category: Ck, T Lundb.]]
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[[Category: Svensson S]]
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[[Category: Cytoplasm]]
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[[Category: Uppenberg J]]
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[[Category: Lipid binding protein]]
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[[Category: Lipid-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 11:24:35 2009''
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Current revision

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors

PDB ID 3fr5

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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