2k7r

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{{Seed}}
 
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[[Image:2k7r.png|left|200px]]
 
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==N-terminal domain of the Bacillus subtilis helicase-loading protein DnaI==
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The line below this paragraph, containing "STRUCTURE_2k7r", creates the "Structure Box" on the page.
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<StructureSection load='2k7r' size='340' side='right'caption='[[2k7r]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K7R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2k7r| PDB=2k7r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k7r OCA], [https://pdbe.org/2k7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k7r RCSB], [https://www.ebi.ac.uk/pdbsum/2k7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k7r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNAI_BACSU DNAI_BACSU] Probably involved in DNA replication.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/2k7r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k7r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The helicase loader protein DnaI (the Bacillus subtilis homologue of Escherichia coli DnaC) is required to load the hexameric helicase DnaC (the B. subtilis homologue of E. coli DnaB) onto DNA at the start of replication. While the C-terminal domain of DnaI belongs to the structurally well-characterized AAA+ family of ATPases, the structure of the N-terminal domain, DnaI-N, has no homology to a known structure. Three-dimensional structure determination by nuclear magnetic resonance (NMR) spectroscopy shows that DnaI presents a novel fold containing a structurally important zinc ion. Surface plasmon resonance experiments indicate that DnaI-N is largely responsible for binding of DnaI to the hexameric helicase from B. stearothermophilus, which is a close homologue of the corresponding much less stable B. subtilis helicase.
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===N-terminal domain of the Bacillus subtilis helicase-loading protein DnaI===
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A novel zinc-binding fold in the helicase interaction domain of the Bacillus subtilis DnaI helicase loader.,Loscha KV, Jaudzems K, Ioannou C, Su XC, Hill FR, Otting G, Dixon NE, Liepinsh E Nucleic Acids Res. 2009 Apr;37(7):2395-404. Epub 2009 Mar 2. PMID:19255093<ref>PMID:19255093</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19255093}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2k7r" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19255093 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19255093}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2K7R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7R OCA].
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==Reference==
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A novel zinc-binding fold in the helicase interaction domain of the Bacillus subtilis DnaI helicase loader., Loscha KV, Jaudzems K, Ioannou C, Su XC, Hill FR, Otting G, Dixon NE, Liepinsh E, Nucleic Acids Res. 2009 Mar 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19255093 19255093]
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Dixon NE]]
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[[Category: Atp-binding]]
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[[Category: Hill FR]]
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[[Category: Dna replication]]
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[[Category: Ioannou C]]
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[[Category: Dnai n-terminal domain]]
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[[Category: Jaudzems K]]
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[[Category: Helicase-loading protein]]
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[[Category: Liepinsh E]]
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[[Category: Nucleotide-binding]]
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[[Category: Loscha KV]]
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[[Category: Primosome]]
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[[Category: Otting G]]
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[[Category: Su XC]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 20:12:00 2009''
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Current revision

N-terminal domain of the Bacillus subtilis helicase-loading protein DnaI

PDB ID 2k7r

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