3dow

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{{Seed}}
 
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[[Image:3dow.jpg|left|200px]]
 
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==Complex structure of GABA type A receptor associated protein and its binding epitope on calreticulin==
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The line below this paragraph, containing "STRUCTURE_3dow", creates the "Structure Box" on the page.
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<StructureSection load='3dow' size='340' side='right'caption='[[3dow]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DOW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3dow| PDB=3dow | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dow OCA], [https://pdbe.org/3dow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dow RCSB], [https://www.ebi.ac.uk/pdbsum/3dow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dow ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/3dow_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dow ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 4-aminobutyrate type A receptor-associated protein (GABARAP) is a versatile adaptor protein that plays an important role in intracellular vesicle trafficking, particularly in neuronal cells. We have investigated the structural determinants underlying the interaction of GABARAP with calreticulin using spectroscopic and crystallographic techniques. Specifically, we present the crystal structure of GABARAP in complex with its major binding epitope on the chaperone. Molecular modeling of a complex containing full-length calreticulin suggests a novel mode of substrate interaction, which may have functional implications for the calreticulin/calnexin family in general.
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===Complex structure of GABA type A receptor associated protein and its binding epitope on calreticulin===
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Structural framework of the GABARAP-calreticulin interface--implications for substrate binding to endoplasmic reticulum chaperones.,Thielmann Y, Weiergraber OH, Mohrluder J, Willbold D FEBS J. 2009 Feb;276(4):1140-52. Epub 2009 Jan 16. PMID:19154346<ref>PMID:19154346</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3dow" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19154346}}, adds the Publication Abstract to the page
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*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19154346 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19154346}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3DOW is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DOW OCA]. Other Useful Biological Numbers at [http://bionumbers.hms.harvard.edu/search.aspx?log=y&task=searchbytrmorg&org=%&trm=calreticulin B10NUMB3R5]
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==Reference==
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<ref group="xtra">PMID:19154346</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Thielmann, Y.]]
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[[Category: Large Structures]]
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[[Category: Weiergraeber, O H.]]
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[[Category: Thielmann Y]]
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[[Category: Willbold, D.]]
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[[Category: Weiergraeber OH]]
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[[Category: Alpha-beta]]
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[[Category: Willbold D]]
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[[Category: Beta-grasp fold]]
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[[Category: Calcium]]
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[[Category: Chaperone]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Extracellular matrix]]
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[[Category: Golgi apparatus]]
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[[Category: Lectin]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Microtubule]]
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[[Category: Protein transport]]
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[[Category: Secreted]]
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[[Category: Transport]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:29:06 2009''
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Current revision

Complex structure of GABA type A receptor associated protein and its binding epitope on calreticulin

PDB ID 3dow

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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