3cc0

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{{Seed}}
 
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[[Image:3cc0.png|left|200px]]
 
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==The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide==
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The line below this paragraph, containing "STRUCTURE_3cc0", creates the "Structure Box" on the page.
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<StructureSection load='3cc0' size='340' side='right'caption='[[3cc0]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cc0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CC0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cc0 OCA], [https://pdbe.org/3cc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cc0 RCSB], [https://www.ebi.ac.uk/pdbsum/3cc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cc0 ProSAT]</span></td></tr>
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{{STRUCTURE_3cc0| PDB=3cc0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3cc0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cc0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dishevelled proteins are key regulators of Wnt signaling pathways that have been implicated in the progression of human cancers. We found that the binding cleft of the Dishevelled PDZ domain is more flexible than those of canonical PDZ domains and enables recognition of both C-terminal and internal peptides. These peptide ligands inhibit Wnt/beta-catenin signaling in cells, showing that Dishevelled PDZ domains are potential targets for small-molecule cancer therapeutics.
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===The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide===
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Inhibition of Wnt signaling by Dishevelled PDZ peptides.,Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS Nat Chem Biol. 2009 Apr;5(4):217-9. Epub 2009 Mar 1. PMID:19252499<ref>PMID:19252499</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3CC0 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC0 OCA].
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<div class="pdbe-citations 3cc0" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Appleton, B A.]]
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[[Category: Large Structures]]
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[[Category: Wiesmann, C.]]
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[[Category: Appleton BA]]
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[[Category: Cytoplasm]]
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[[Category: Wiesmann C]]
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[[Category: Developmental protein]]
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[[Category: Pdz domain]]
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[[Category: Phage derived high affinity ligand]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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[[Category: Signaling protein]]
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[[Category: Wnt signaling pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 18 20:04:22 2009''
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Current revision

The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide

PDB ID 3cc0

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