2zuw

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{{Seed}}
 
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[[Image:2zuw.png|left|200px]]
 
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==Crystal structure of Galacto-N-biose/Lacto-N-biose I phosphorylase in complex with GlcNAc and sulfate==
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The line below this paragraph, containing "STRUCTURE_2zuw", creates the "Structure Box" on the page.
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<StructureSection load='2zuw' size='340' side='right'caption='[[2zuw]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zuw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZUW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2zuw| PDB=2zuw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zuw OCA], [https://pdbe.org/2zuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zuw RCSB], [https://www.ebi.ac.uk/pdbsum/2zuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zuw ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Galacto-N-biose/Lacto-N-biose I phosphorylase in complex with GlcNAc and sulfate===
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== Function ==
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[https://www.uniprot.org/uniprot/LNPA_BIFL2 LNPA_BIFL2] Reversibly phosphorolyzes lacto-N-biose to Gal1-P and N-acetylglucosamine (GlcNAc) and galacto-N-biose to Gal1-P and N-acetylgalactosamine (GalNAc). Involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria.<ref>PMID:15933016</ref> <ref>PMID:17720833</ref> <ref>PMID:19124470</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19124470}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19124470 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zu/2zuw_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19124470}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2ZUW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUW OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zuw ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The Crystal Structure of Galacto-N-biose/Lacto-N-biose I Phosphorylase: A LARGE DEFORMATION OF A TIM BARREL SCAFFOLD., Hidaka M, Nishimoto M, Kitaoka M, Wakagi T, Shoun H, Fushinobu S, J Biol Chem. 2009 Mar 13;284(11):7273-83. Epub 2009 Jan 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19124470 19124470]
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<references/>
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__TOC__
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Novel putative galactose operon involving lacto-N-biose phosphorylase in Bifidobacterium longum., Kitaoka M, Tian J, Nishimoto M, Appl Environ Microbiol. 2005 Jun;71(6):3158-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15933016 15933016]
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</StructureSection>
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[[Category: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase]]
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[[Category: Bifidobacterium longum]]
[[Category: Bifidobacterium longum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Fushinobu S]]
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[[Category: Beta-alpha-barrel]]
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[[Category: Hidaka M]]
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[[Category: Glycosyltransferase]]
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[[Category: Kitaoka M]]
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[[Category: Tim barrel]]
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[[Category: Nishimoto M]]
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[[Category: Transferase]]
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[[Category: Shoun H]]
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[[Category: Wakagi T]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 18 20:27:48 2009''
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Current revision

Crystal structure of Galacto-N-biose/Lacto-N-biose I phosphorylase in complex with GlcNAc and sulfate

PDB ID 2zuw

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