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3g80

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'''Unreleased structure'''
 
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The entry 3g80 is ON HOLD until Paper Publication
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==Nodamura virus protein b2, RNA-binding domain==
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<StructureSection load='3g80' size='340' side='right'caption='[[3g80]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3g80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nodamura_virus Nodamura virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G80 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g80 OCA], [https://pdbe.org/3g80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g80 RCSB], [https://www.ebi.ac.uk/pdbsum/3g80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g80 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2_NODAM B2_NODAM] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:19249868</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein B2 from Nodamura virus (NMV B2), a member of the Nodavirus family, acts as a suppressor of RNA interference (RNAi). The N-terminal domain of NMV B2, consisting of residues 1-79, recognizes double-stranded RNA (dsRNA). The 2.5 A crystal structure of the RNA-binding domain of NMV B2 shows a dimeric, helical bundle structure. The structure shows a conserved set of RNA-binding residues compared with flock house virus B2, despite limited sequence identity. The crystal packing places the RNA-binding residues along one face of symmetry-related molecules, suggesting a potential platform for recognition of dsRNA.
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Authors: Koerber, S., Ali, P.S., Chen, J.C.H.
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Structure of the RNA-Binding Domain of Nodamura Virus Protein B2, a Suppressor of RNA Interference (dagger) , (double dagger).,Korber S, Shaik Syed Ali P, Chen JC Biochemistry. 2009 Mar 24;48(11):2307-9. PMID:19249868<ref>PMID:19249868</ref>
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Description: Nodamura virus protein b2, RNA-binding domain
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:24:05 2009''
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<div class="pdbe-citations 3g80" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Nodamura virus]]
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[[Category: Chen JC]]
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[[Category: Korber S]]
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[[Category: Shaik Syed Ali P]]

Current revision

Nodamura virus protein b2, RNA-binding domain

PDB ID 3g80

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