3bbp

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{{Seed}}
 
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[[Image:3bbp.png|left|200px]]
 
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==Rab6-GTP:GCC185 Rab binding domain complex==
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The line below this paragraph, containing "STRUCTURE_3bbp", creates the "Structure Box" on the page.
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<StructureSection load='3bbp' size='340' side='right'caption='[[3bbp]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bbp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BBP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3bbp| PDB=3bbp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bbp OCA], [https://pdbe.org/3bbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bbp RCSB], [https://www.ebi.ac.uk/pdbsum/3bbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bbp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/3bbp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bbp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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GCC185 is a large coiled-coil protein at the trans Golgi network that is required for receipt of transport vesicles inbound from late endosomes and for anchoring noncentrosomal microtubules that emanate from the Golgi. Here, we demonstrate that recruitment of GCC185 to the Golgi is mediated by two Golgi-localized small GTPases of the Rab and Arl families. GCC185 binds Rab6, and mutation of residues needed for Rab binding abolishes Golgi localization. The crystal structure of Rab6 bound to the GCC185 Rab-binding domain reveals that Rab6 recognizes a two-fold symmetric surface on a coiled coil immediately adjacent to a C-terminal GRIP domain. Unexpectedly, Rab6 binding promotes association of Arl1 with the GRIP domain. We present a structure-derived model for dual GTPase membrane attachment that highlights the potential ability of Rab GTPases to reach binding partners at a significant distance from the membrane via their unstructured and membrane-anchored, hypervariable domains.
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===Rab6-GTP:GCC185 Rab binding domain complex===
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Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.,Burguete AS, Fenn TD, Brunger AT, Pfeffer SR Cell. 2008 Jan 25;132(2):286-98. PMID:18243103<ref>PMID:18243103</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3bbp" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18243103}}, adds the Publication Abstract to the page
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18243103 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18243103}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3BBP is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BBP OCA].
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==Reference==
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<ref group="xtra">PMID:18243103</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brunger, A T.]]
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[[Category: Large Structures]]
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[[Category: Burguete, A Schweizer.]]
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[[Category: Brunger AT]]
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[[Category: Fenn, T D.]]
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[[Category: Fenn TD]]
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[[Category: Pfeffer, S R.]]
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[[Category: Pfeffer SR]]
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[[Category: Acetylation]]
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[[Category: Schweizer Burguete A]]
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[[Category: Alternative splicing]]
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[[Category: Arl gtpase]]
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[[Category: Clasp protein]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Er-golgi transport]]
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[[Category: Golgi apparatus]]
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[[Category: Golgi complex]]
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[[Category: Golgin]]
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[[Category: Grip domain]]
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[[Category: Gtp-binding]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Methylation]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
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[[Category: Prenylation]]
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[[Category: Protein transport]]
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[[Category: Protein transport/splicing complex]]
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[[Category: Rab effector]]
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[[Category: Rab gtpase]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:53:10 2009''
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Current revision

Rab6-GTP:GCC185 Rab binding domain complex

PDB ID 3bbp

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OCA

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