2jda

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{{Seed}}
 
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[[Image:2jda.png|left|200px]]
 
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==Structure of a pectin binding carbohydrate binding module determined in an monoclinic crystal form.==
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The line below this paragraph, containing "STRUCTURE_2jda", creates the "Structure Box" on the page.
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<StructureSection load='2jda' size='340' side='right'caption='[[2jda]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JDA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2jda| PDB=2jda | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jda OCA], [https://pdbe.org/2jda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jda RCSB], [https://www.ebi.ac.uk/pdbsum/2jda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jda ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A1JSS7_YERE8 A1JSS7_YERE8]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jd/2jda_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jda ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A number of bacteria in the family Enterobacteriaceae harbor the genes comprising well-developed pectinolytic pathways (e.g. Erwinia sp.) or abridged versions of this pathway (e.g. Yersinia sp.). One of the most enigmatic components present in some of these pathways is a small gene that encodes a predicted secreted protein of approximately 160 amino acid residues with unknown function. This protein shows distant amino acid sequence similarity over its entire length to galactose-specific family 32 carbohydrate-binding modules (CBMs). Here we demonstrate the ability of the Yersinia enterocolitica example, here called YeCBM32, to bind polygalacturonic acid containing components of pectin. This binding is selective for highly polymerized galacturonic acid and shows a complex mode of polysaccharide recognition. The high resolution X-ray crystal structure (1.35 A) shows YeCBM32s overall structural similarity to galactose specific CBMs and conserved binding site location but reveals a substantially different binding site topology, which likely reflects its unique polymeric and acidic ligand. The results suggest the possibility of a unique role for YeCBM32 in polygalacturonic acid transport.
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===STRUCTURE OF A PECTIN BINDING CARBOHYDRATE BINDING MODULE DETERMINED IN AN MONOCLINIC CRYSTAL FORM.===
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Identification and characterization of a novel periplasmic polygalacturonic acid binding protein from Yersinia enterolitica.,Abbott DW, Hrynuik S, Boraston AB J Mol Biol. 2007 Apr 6;367(4):1023-33. Epub 2007 Jan 13. PMID:17292916<ref>PMID:17292916</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17292916}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jda" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17292916 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17292916}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2JDA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDA OCA].
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==Reference==
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<ref group="xtra">PMID:17292916</ref><references group="xtra"/>
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[[Category: Yersinia enterocolitica]]
[[Category: Yersinia enterocolitica]]
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[[Category: Abbott, D W.]]
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[[Category: Abbott DW]]
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[[Category: Boraston, A B.]]
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[[Category: Boraston AB]]
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[[Category: Carbohydrate- binding module]]
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[[Category: Galacturonic acid]]
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[[Category: Hypothetical protein]]
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[[Category: Pectin]]
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[[Category: Plant cell wall]]
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[[Category: Sugar-binding protein]]
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[[Category: Yersinia enterocolitica]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:58:02 2009''
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Current revision

Structure of a pectin binding carbohydrate binding module determined in an monoclinic crystal form.

PDB ID 2jda

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