2wci
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2wci is ON HOLD Authors: Iwema, T., Picchiocci, A., Traore, D.A.K., Ferrer, J.-L., Chauvat, F., Jacquamet, L. Description: Structure of E. coli mon...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of E. coli monothiol glutaredoxin GRX4 homodimer== | |
| + | <StructureSection load='2wci' size='340' side='right'caption='[[2wci]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2wci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wci OCA], [https://pdbe.org/2wci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wci RCSB], [https://www.ebi.ac.uk/pdbsum/2wci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wci ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLRX4_ECOLI GLRX4_ECOLI] Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/2wci_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wci ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Glutaredoxins (GRX) are redox proteins which use glutathione as a cofactor and are divided into two classes, monothiol and dithiol. In each class, several GRX have been shown to form [Fe2S2] cluster coordinating homodimers. The dithiol GRX homodimer is proposed to serve as a sequestration form and its iron-sulfur cluster as an oxidative stress sensor. In contrast, the monothiol GRX homodimer has been suggested to act as a scaffold for [Fe2S2] cluster delivery. We present here the structure of a monothiol GRX homodimer (Escherichia coli GRX4) coordinating a [Fe2S2] cluster that reveals the structural basis of intact iron-sulfur cluster delivery. | ||
| - | + | Structural Basis for Delivery of the Intact [Fe2S2] Cluster by Monothiol Glutaredoxin.,Iwema T, Picciocchi A, Traore DA, Ferrer JL, Chauvat F, Jacquamet L Biochemistry. 2009 Jun 15. PMID:19505088<ref>PMID:19505088</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2wci" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chauvat F]] | ||
| + | [[Category: Ferrer J-L]] | ||
| + | [[Category: Iwema T]] | ||
| + | [[Category: Jacquamet L]] | ||
| + | [[Category: Picchiocci A]] | ||
| + | [[Category: Traore DAK]] | ||
Current revision
Structure of E. coli monothiol glutaredoxin GRX4 homodimer
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