This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2wcn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2wcn is ON HOLD Authors: Nielsen, J.T., Arar, K., Petersen, M. Description: Solution structure of an LNA-modified quadruplex ''Page seeded by [htt...) |
|||
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of an LNA-modified quadruplex== | |
| + | <StructureSection load='2wcn' size='340' side='right'caption='[[2wcn]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2wcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcn OCA], [https://pdbe.org/2wcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wcn RCSB], [https://www.ebi.ac.uk/pdbsum/2wcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wcn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Sharp curves: The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V-shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology. | ||
| - | + | Solution structure of a locked nucleic acid modified quadruplex: introducing the V4 folding topology.,Nielsen JT, Arar K, Petersen M Angew Chem Int Ed Engl. 2009;48(17):3099-103. PMID:19308940<ref>PMID:19308940</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2wcn" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sterkiella nova]] | ||
| + | [[Category: Arar K]] | ||
| + | [[Category: Nielsen JT]] | ||
| + | [[Category: Petersen M]] | ||
Current revision
Solution structure of an LNA-modified quadruplex
| |||||||||||
