3clh

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{{Seed}}
 
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[[Image:3clh.jpg|left|200px]]
 
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==Crystal structure of 3-dehydroquinate synthase (DHQS)from Helicobacter pylori==
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The line below this paragraph, containing "STRUCTURE_3clh", creates the "Structure Box" on the page.
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<StructureSection load='3clh' size='340' side='right'caption='[[3clh]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3clh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CLH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3clh| PDB=3clh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3clh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3clh OCA], [https://pdbe.org/3clh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3clh RCSB], [https://www.ebi.ac.uk/pdbsum/3clh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3clh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AROB_HELPY AROB_HELPY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3clh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3clh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dehydroquinate synthase (DHQS) is a nicotinamide adenine dinucleotide (NAD)-dependent enzyme that converts 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) into 3-dehydroquinate (DHQ). Since it catalyzes the second key step in the shikimate pathway, which is crucial for the aromatic amino acid metabolism in bacteria, fungi, and plants, but not in mammals, DHQS is a potential target for new antimicrobial agents, anti-parasitic agents and herbicides. The crystal structure of Helicobacter pylori DHQS (HpDHQS) complexed with NAD has been determined at 2.4-A resolution and was found to possess an N-terminal Rossmann-fold domain and a C-terminal alpha-helical domain. Structural comparison reveals that the binary complex adopts an open-state conformation and shares conserved residues in the binding pocket. Virtual docking of compounds into the active site of the HpDHQS structure using the GOLD docking program led to the identification of several inhibitors. The most active compound had an IC(50) value of 61 microM, which may serve as a lead for potent inhibitors.
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===Crystal structure of 3-dehydroquinate synthase (DHQS)from Helicobacter pylori===
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Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase.,Liu JS, Cheng WC, Wang HJ, Chen YC, Wang WC Biochem Biophys Res Commun. 2008 Aug 15;373(1):1-7. Epub 2008 May 27. PMID:18503755<ref>PMID:18503755</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18503755}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3clh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18503755 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18503755}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3CLH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLH OCA].
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==Reference==
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<ref group="xtra">PMID:18503755</ref><references group="xtra"/>
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[[Category: 3-dehydroquinate synthase]]
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Chen, Y C.]]
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[[Category: Large Structures]]
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[[Category: Cheng, W C.]]
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[[Category: Chen YC]]
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[[Category: Liu, J S.]]
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[[Category: Cheng WC]]
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[[Category: Wang, H J.]]
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[[Category: Liu JS]]
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[[Category: Wang, W C.]]
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[[Category: Wang HJ]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Wang WC]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Cytoplasm]]
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[[Category: Dhq]]
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[[Category: Lyase]]
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[[Category: Nad]]
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[[Category: Shikimate pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 12:23:26 2009''
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Current revision

Crystal structure of 3-dehydroquinate synthase (DHQS)from Helicobacter pylori

PDB ID 3clh

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