1e07

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{{Seed}}
 
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[[Image:1e07.png|left|200px]]
 
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==Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data==
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The line below this paragraph, containing "STRUCTURE_1e07", creates the "Structure Box" on the page.
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<StructureSection load='1e07' size='340' side='right'caption='[[1e07]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1e07]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E07 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e07 OCA], [https://pdbe.org/1e07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e07 RCSB], [https://www.ebi.ac.uk/pdbsum/1e07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e07 ProSAT]</span></td></tr>
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{{STRUCTURE_1e07| PDB=1e07 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CEAM5_HUMAN CEAM5_HUMAN] Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.<ref>PMID:10864933</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/1e07_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e07 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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MFE23 is a single chain Fv antibody that has a high affinity for carcinoembryonic antigen (CEA). A full homology model for CEA based on V-type, I-type and C2-type immunoglobulin folds, 28 oligosaccharides and the interdomain angle of CD2 was validated using solution scattering data. The superimposition of the intermolecular contacts observed in our recent crystal structure of MFE23 with the N-terminal domain of CEA permitted the MFE23-CEA complex to be modelled. Good surface and electrostatic complementarity and carbohydrate-unhindered access of MFE23 with the indentation between the first two CEA domains was observed. The model is supported by biochemical data and provides insight on the high affinity of MFE23 for CEA.
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===MODEL OF HUMAN CARCINOEMBRYONIC ANTIGEN BY HOMOLOGY MODELLING AND CURVE-FITTING TO EXPERIMENTAL SOLUTION SCATTERING DATA===
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Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23.,Boehm MK, Perkins SJ FEBS Lett. 2000 Jun 9;475(1):11-6. PMID:10854848<ref>PMID:10854848</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10854848}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1e07" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10854848 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10854848}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1E07 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E07 OCA].
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==Reference==
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Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23., Boehm MK, Perkins SJ, FEBS Lett. 2000 Jun 9;475(1):11-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10854848 10854848]
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Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts., Boehm MK, Corper AL, Wan T, Sohi MK, Sutton BJ, Thornton JD, Keep PA, Chester KA, Begent RH, Perkins SJ, Biochem J. 2000 Mar 1;346 Pt 2:519-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10677374 10677374]
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Extended glycoprotein structure of the seven domains in human carcinoembryonic antigen by X-ray and neutron solution scattering and an automated curve fitting procedure: implications for cellular adhesion., Boehm MK, Mayans MO, Thornton JD, Begent RH, Keep PA, Perkins SJ, J Mol Biol. 1996 Jun 21;259(4):718-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8683578 8683578]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Boehm MK]]
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[[Category: Calpha only]]
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[[Category: Perkins SJ]]
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[[Category: Cea]]
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[[Category: Glycoprotein]]
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[[Category: Immunoglobulin-fold]]
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[[Category: Tumour marker]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 20:09:04 2009''
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Current revision

Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data

PDB ID 1e07

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