3d6a

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{{Seed}}
 
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[[Image:3d6a.png|left|200px]]
 
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==Crystal structure of the 2H-phosphatase domain of Sts-2 in complex with tungstate.==
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The line below this paragraph, containing "STRUCTURE_3d6a", creates the "Structure Box" on the page.
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<StructureSection load='3d6a' size='340' side='right'caption='[[3d6a]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d6a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D6A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>
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{{STRUCTURE_3d6a| PDB=3d6a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d6a OCA], [https://pdbe.org/3d6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d6a RCSB], [https://www.ebi.ac.uk/pdbsum/3d6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d6a ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the 2H-phosphatase domain of Sts-2 in complex with tungstate.===
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== Function ==
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[https://www.uniprot.org/uniprot/UBS3A_MOUSE UBS3A_MOUSE] Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.<ref>PMID:19196006</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19196006 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/3d6a_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19196006}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3D6A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6A OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d6a ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structural and Functional Characterization of the 2H-Phosphatase Domain of Sts-2 Reveals an Acid-Dependent Phosphatase Activity (dagger)., Chen Y, Jakoncic J, Carpino N, Nassar N, Biochemistry. 2009 Feb 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19196006 19196006]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Carpino N]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Chen Y]]
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[[Category: 2h-phosphatase]]
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[[Category: Nassar N]]
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[[Category: Hydrolase]]
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[[Category: Pgm domain]]
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[[Category: Sh3 domain]]
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[[Category: Tungstate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 20:51:49 2009''
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Current revision

Crystal structure of the 2H-phosphatase domain of Sts-2 in complex with tungstate.

PDB ID 3d6a

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