2b3x

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{{Seed}}
 
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[[Image:2b3x.png|left|200px]]
 
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==Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)==
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The line below this paragraph, containing "STRUCTURE_2b3x", creates the "Structure Box" on the page.
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<StructureSection load='2b3x' size='340' side='right'caption='[[2b3x]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b3x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B3X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2b3x| PDB=2b3x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3x OCA], [https://pdbe.org/2b3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b3x RCSB], [https://www.ebi.ac.uk/pdbsum/2b3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACOHC_HUMAN ACOHC_HUMAN] Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1946430, PubMed:1281544, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004).<ref>PMID:1281544</ref> <ref>PMID:1946430</ref> <ref>PMID:23891004</ref> <ref>PMID:8041788</ref> Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.<ref>PMID:1281544</ref> <ref>PMID:1946430</ref> <ref>PMID:8041788</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b3x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b3x ConSurf].
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<div style="clear:both"></div>
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===Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)===
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==See Also==
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*[[Aconitase 3D structures|Aconitase 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16407072 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16407072}}
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==About this Structure==
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2B3X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3X OCA].
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==Reference==
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Crystal structure of human iron regulatory protein 1 as cytosolic aconitase., Dupuy J, Volbeda A, Carpentier P, Darnault C, Moulis JM, Fontecilla-Camps JC, Structure. 2006 Jan;14(1):129-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16407072 16407072]
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[[Category: Aconitate hydratase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Dupuy J]]
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[[Category: Irp1 ire-irp1 aconitase activity]]
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[[Category: Fontecilla-Camps JC]]
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[[Category: Lyase]]
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[[Category: Volbeda A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 21:07:00 2009''
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Current revision

Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)

PDB ID 2b3x

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