2vqp

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{{Seed}}
 
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[[Image:2vqp.png|left|200px]]
 
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==Structure of the matrix protein from human Respiratory Syncytial Virus==
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The line below this paragraph, containing "STRUCTURE_2vqp", creates the "Structure Box" on the page.
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<StructureSection load='2vqp' size='340' side='right'caption='[[2vqp]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A2 Human respiratory syncytial virus A2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VQP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2vqp| PDB=2vqp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqp OCA], [https://pdbe.org/2vqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vqp RCSB], [https://www.ebi.ac.uk/pdbsum/2vqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MATRX_HRSVA MATRX_HRSVA] Has a crucial role in virus assembly and budding. The matrix interacts with the RNP complex and this association serves two functions: facilitate virion assembly and inhibit the viral transcriptase activity. Early in infection, M is localized to the nucleus and may inhibit host cell transcription. Later on, M can associate with lipid rafts supposely by interacting with the cytoskeleton and with the cytoplasmic tail of glycoprotein G. The binding of M to host membrane is stabilized by the surface expression of the viral glycoproteins. These interactions may allow virus formation by mediating association of the nucleocapsid with the nascent envelop.<ref>PMID:11907323</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vq/2vqp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vqp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The matrix protein (M) of respiratory syncytial virus (RSV), the prototype viral member of the Pneumovirinae (family Paramyxoviridae, order Mononegavirales), has been crystallized and the structure determined to a resolution of 1.6 A. The structure comprises 2 compact beta-rich domains connected by a relatively unstructured linker region. Due to the high degree of side-chain order in the structure, an extensive contiguous area of positive surface charge covering approximately 600 A(2) can be resolved. This unusually large patch of positive surface potential spans both domains and the linker, and provides a mechanism for driving the interaction of the protein with a negatively-charged membrane surface or other virion components such as the nucleocapsid. This patch is complemented by regions of high hydrophobicity and a striking planar arrangement of tyrosine residues encircling the C-terminal domain. Comparison of the RSV M sequence with other members of the Pneumovirinae shows that regions of divergence correspond to surface exposed loops in the M structure, with the majority of viral species-specific differences occurring in the N-terminal domain.
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===STRUCTURE OF THE MATRIX PROTEIN FROM HUMAN RESPIRATORY SYNCYTIAL VIRUS===
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Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction.,Money VA, McPhee HK, Mosely JA, Sanderson JM, Yeo RP Proc Natl Acad Sci U S A. 2009 Feb 26. PMID:19251668<ref>PMID:19251668</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_19251668}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2vqp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19251668 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19251668}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human respiratory syncytial virus A2]]
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2VQP is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_a2 Human respiratory syncytial virus a2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQP OCA].
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[[Category: Large Structures]]
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[[Category: McPhee HK]]
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==Reference==
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[[Category: Money VA]]
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<ref group="xtra">PMID:19251668</ref><references group="xtra"/>
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[[Category: Sanderson JM]]
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[[Category: Human respiratory syncytial virus a2]]
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[[Category: Yeo RP]]
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[[Category: Mcphee, H K.]]
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[[Category: Money, V A.]]
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[[Category: Sanderson, J M.]]
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[[Category: Yeo, R P.]]
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[[Category: Envelope protein]]
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[[Category: Matrix protein]]
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[[Category: Peripheral membrane protein]]
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[[Category: Rsv]]
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[[Category: Viral matrix protein]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 16:20:21 2009''
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Current revision

Structure of the matrix protein from human Respiratory Syncytial Virus

PDB ID 2vqp

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OCA

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