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2w51

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{{Seed}}
 
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[[Image:2w51.png|left|200px]]
 
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==Human mesencephalic astrocyte-derived neurotrophic factor (MANF)==
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The line below this paragraph, containing "STRUCTURE_2w51", creates the "Structure Box" on the page.
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<StructureSection load='2w51' size='340' side='right'caption='[[2w51]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w51]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W51 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w51 OCA], [https://pdbe.org/2w51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w51 RCSB], [https://www.ebi.ac.uk/pdbsum/2w51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w51 ProSAT]</span></td></tr>
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{{STRUCTURE_2w51| PDB=2w51 | SCENE= }}
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</table>
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== Disease ==
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===HUMAN MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR (MANF)===
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[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Familial pancreatic carcinoma.
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== Function ==
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[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref>
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_19258449}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19258449 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_19258449}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w51_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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2W51 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W51 OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w51 ConSurf].
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==Reference==
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<div style="clear:both"></div>
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<ref group="xtra">PMID:19258449</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Goldman, A.]]
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[[Category: Large Structures]]
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[[Category: Kalkkinen, N.]]
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[[Category: Goldman A]]
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[[Category: Leppanen, V M.]]
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[[Category: Kalkkinen N]]
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[[Category: Lindholm, P.]]
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[[Category: Leppanen VM]]
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[[Category: Oksanen, E.]]
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[[Category: Lindholm P]]
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[[Category: Parkash, V.]]
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[[Category: Oksanen E]]
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[[Category: Peranen, J.]]
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[[Category: Parkash V]]
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[[Category: Saarma, M.]]
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[[Category: Peranen J]]
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[[Category: Cdnf]]
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[[Category: Saarma M]]
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[[Category: Er stress]]
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[[Category: Glycoprotein]]
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[[Category: Growth factor]]
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[[Category: Hormone]]
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[[Category: Manf]]
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[[Category: Neurotrophic factor]]
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[[Category: Phosphoprotein]]
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[[Category: Saposin]]
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[[Category: Secreted]]
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[[Category: Sialic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 16:20:37 2009''
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Current revision

Human mesencephalic astrocyte-derived neurotrophic factor (MANF)

PDB ID 2w51

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