3gam

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{{Seed}}
 
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[[Image:3gam.png|left|200px]]
 
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==Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory activity==
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The line below this paragraph, containing "STRUCTURE_3gam", creates the "Structure Box" on the page.
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<StructureSection load='3gam' size='340' side='right'caption='[[3gam]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gam]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GAM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MXX:5,8-DIMETHOXY-1,4-DIMETHYLQUINOLIN-2(1H)-ONE'>MXX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3gam| PDB=3gam | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gam OCA], [https://pdbe.org/3gam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gam RCSB], [https://www.ebi.ac.uk/pdbsum/3gam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gam ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3gam_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gam ConSurf].
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<div style="clear:both"></div>
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===Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory activity===
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==See Also==
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*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19265439}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19265439 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19265439}}
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==About this Structure==
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3GAM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAM OCA].
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==Reference==
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<ref group="xtra">PMID:19265439</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cushman, M.]]
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[[Category: Large Structures]]
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[[Category: Maiti, A.]]
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[[Category: Cushman M]]
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[[Category: Marler, L.]]
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[[Category: Maiti A]]
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[[Category: Mesecar, A D.]]
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[[Category: Marler L]]
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[[Category: Pegan, S D.]]
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[[Category: Mesecar AD]]
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[[Category: Pezzuto, J M.]]
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[[Category: Pegan SD]]
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[[Category: Sturdy, M.]]
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[[Category: Pezzuto JM]]
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[[Category: Casimiroin]]
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[[Category: Sturdy M]]
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[[Category: Cytoplasm]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Hqo2]]
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[[Category: Metal-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Qr2]]
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[[Category: Quinone reductase 2]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:21:46 2009''
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Current revision

Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory activity

PDB ID 3gam

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