3f5v

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{{Seed}}
 
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[[Image:3f5v.png|left|200px]]
 
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==C2 Crystal form of mite allergen DER P 1==
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The line below this paragraph, containing "STRUCTURE_3f5v", creates the "Structure Box" on the page.
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<StructureSection load='3f5v' size='340' side='right'caption='[[3f5v]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3f5v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
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{{STRUCTURE_3f5v| PDB=3f5v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5v OCA], [https://pdbe.org/3f5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5v RCSB], [https://www.ebi.ac.uk/pdbsum/3f5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q3HWZ5_DERPT Q3HWZ5_DERPT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/3f5v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f5v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The group 1 mite allergens Der f 1 and Der p 1 are potent allergens excreted by Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively. The human immunoglobulin E antibody responses to the group 1 allergens show more cross-reactivity than the murine immunoglobulin G antibody responses, which are largely species specific. Here, we report the crystal structure of the mature form of Der f 1, which was isolated from its natural source, and a new high-resolution structure of mature recombinant Der p 1. Unlike Der p 1, Der f 1 is monomeric both in the crystalline state and in solution. Moreover, no metal binding is observed in the structure of Der f 1 despite the fact that all amino acids involved in Ca(2+) binding in Der p 1 are completely conserved in Der f 1. Although Der p 1 and Der f 1 share an extensive sequence identity, comparison of the crystal structures of both allergens revealed structural features that could explain the differences in murine IgG and human IgE antibody responses to these allergens. There are structural differences between Der f 1 and Der p 1 that are unevenly distributed on the allergens' surfaces. This uneven spatial arrangement of conserved versus altered residues could explain both the specificity and cross-reactivity of antibodies against Der f 1 and Der p 1.
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===C2 Crystal form of mite allergen DER P 1===
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Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding.,Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomes A J Mol Biol. 2009 Feb 20;386(2):520-30. Epub 2008 Dec 30. PMID:19136006<ref>PMID:19136006</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19136006}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3f5v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19136006 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19136006}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3F5V is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5V OCA].
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==Reference==
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<ref group="xtra">PMID:19136006</ref><references group="xtra"/>
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[[Category: Dermatophagoides pteronyssinus]]
[[Category: Dermatophagoides pteronyssinus]]
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[[Category: Chruszcz, M.]]
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[[Category: Large Structures]]
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[[Category: Minor, W.]]
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[[Category: Chruszcz M]]
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[[Category: Remy, J M.Saint.]]
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[[Category: Minor W]]
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[[Category: Stura, E A.]]
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[[Category: Saint Remy JM]]
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[[Category: Allergen]]
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[[Category: Stura EA]]
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[[Category: Allergy]]
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[[Category: Asthma]]
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[[Category: Dust mite]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Secreted]]
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[[Category: Thiol protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:24:58 2009''
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Current revision

C2 Crystal form of mite allergen DER P 1

PDB ID 3f5v

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