2khn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2khn is ON HOLD Authors: Mills, J.L., Ghosh, A., Garcia, E., Zhang, Q., Shastry, R., Foote, E.L., Janjua, H., Acton, T.B., Xiao, R., Everett, J.K., ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.== | |
| + | <StructureSection load='2khn' size='340' side='right'caption='[[2khn]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [https://pdbe.org/2khn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [https://www.ebi.ac.uk/pdbsum/2khn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khn ProSAT], [https://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kh/2khn_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2khn ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Intersectin|Intersectin]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Acton TB]] | ||
| + | [[Category: Everett JK]] | ||
| + | [[Category: Foote EL]] | ||
| + | [[Category: Garcia E]] | ||
| + | [[Category: Ghosh A]] | ||
| + | [[Category: Janjua H]] | ||
| + | [[Category: Mills JL]] | ||
| + | [[Category: Montelione GT]] | ||
| + | [[Category: Shastry R]] | ||
| + | [[Category: Szyperski T]] | ||
| + | [[Category: Xiao R]] | ||
| + | [[Category: Zhang Q]] | ||
Current revision
NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.
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Categories: Homo sapiens | Large Structures | Acton TB | Everett JK | Foote EL | Garcia E | Ghosh A | Janjua H | Mills JL | Montelione GT | Shastry R | Szyperski T | Xiao R | Zhang Q
