2wek

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 2wek is ON HOLD Authors: Shafqat, N., Yue, W.W., Ugochukwu, E., Niesen, F., Smee, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Opperma...)
Current revision (15:53, 13 December 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 2wek is ON HOLD
+
==Crystal structure of the human MGC45594 gene product in complex with diclofenac==
-
 
+
<StructureSection load='2wek' size='340' side='right'caption='[[2wek]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
Authors: Shafqat, N., Yue, W.W., Ugochukwu, E., Niesen, F., Smee, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2wek]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEK FirstGlance]. <br>
-
Description: Crystal structure of the human MGC45594 gene product in complex with diclofenac
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIF:2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC+ACID'>DIF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:43:29 2009''
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wek OCA], [https://pdbe.org/2wek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wek RCSB], [https://www.ebi.ac.uk/pdbsum/2wek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wek ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wek_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wek ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith C]]
 +
[[Category: Bountra C]]
 +
[[Category: Edwards A]]
 +
[[Category: Niesen F]]
 +
[[Category: Oppermann U]]
 +
[[Category: Shafqat N]]
 +
[[Category: Smee C]]
 +
[[Category: Ugochukwu E]]
 +
[[Category: Weigelt J]]
 +
[[Category: Yue WW]]

Current revision

Crystal structure of the human MGC45594 gene product in complex with diclofenac

PDB ID 2wek

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wek"
Personal tools