This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3gio

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:41, 13 December 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 3gio is ON HOLD until sometime in the future
+
==Crystal structure of the TNF-alpha inducing protein (Tip alpha) from Helicobacter pylori==
 +
<StructureSection load='3gio' size='340' side='right'caption='[[3gio]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3gio]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GIO FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gio OCA], [https://pdbe.org/3gio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gio RCSB], [https://www.ebi.ac.uk/pdbsum/3gio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gio ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/O25318_HELPY O25318_HELPY]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Helicobacter pylori infection is one of the highest risk factors for gastroduodenal diseases including gastric cancer. Tumor necrosis factor-alpha (TNF-alpha) is one of the essential cytokines for tumor promotion, and thus, an H. pylori protein that induces TNF-alpha is believed to play a significant role in gastric cancer development in humans. The HP0596 gene product of H. pylori strain 26695 was identified as the TNF-alpha-inducing protein (Tipalpha). Tipalpha is secreted from H. pylori as dimers and enters the gastric cells. It was shown to have a DNA-binding activity. Here, we have determined the crystal structure of Tipalpha from H. pylori. Its monomer consists of two structural domains ("mixed domain" and "helical domain"). Tipalpha exists as a dimer in the crystal, and the dimeric structure represents a novel scaffold for DNA binding. A positively charged surface patch formed across the two monomers of the Tipalpha dimer by the loop between helices alpha1 and alpha2 may be important in DNA binding.
-
Authors: Jang, J.Y., Yoon, H.J., Yoon, J.Y., Kim, H.S., Lee, S.J., Kim, K.H., Kim, D.J., Han, B., Lee, B.I., Jang, S., Suh, S.W.
+
Crystal structure of the TNF-alpha-Inducing protein (Tipalpha) from Helicobacter pylori: Insights into Its DNA-binding activity.,Jang JY, Yoon HJ, Yoon JY, Kim HS, Lee SJ, Kim KH, Kim do J, Jang S, Han BG, Lee BI, Suh SW J Mol Biol. 2009 Sep 11;392(1):191-7. Epub 2009 Jul 10. PMID:19596016<ref>PMID:19596016</ref>
-
Description: Crystal structure of the TNF-alpha inducing protein (Tip alpha) from Helicobacter pylori
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:53:59 2009''
+
<div class="pdbe-citations 3gio" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Helicobacter pylori]]
 +
[[Category: Large Structures]]
 +
[[Category: Han BG]]
 +
[[Category: Jang JY]]
 +
[[Category: Jang S]]
 +
[[Category: Kim DJ]]
 +
[[Category: Kim HS]]
 +
[[Category: Kim KH]]
 +
[[Category: Lee BI]]
 +
[[Category: Lee SJ]]
 +
[[Category: Suh SW]]
 +
[[Category: Yoon HJ]]
 +
[[Category: Yoon JY]]

Current revision

Crystal structure of the TNF-alpha inducing protein (Tip alpha) from Helicobacter pylori

PDB ID 3gio

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3gio"
Personal tools