3gt9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 3gt9 is ON HOLD Authors: Franklin, M.C., Fairbrother, W.J., Cohen, F. Description: Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic '...)
Current revision (09:56, 21 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 3gt9 is ON HOLD
+
==Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic==
-
 
+
<StructureSection load='3gt9' size='340' side='right'caption='[[3gt9]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
Authors: Franklin, M.C., Fairbrother, W.J., Cohen, F.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3gt9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GT9 FirstGlance]. <br>
-
Description: Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=516:N-{(1S)-1-CYCLOHEXYL-2-[(2S)-2-(4-NAPHTHALEN-1-YL-1,3-THIAZOL-2-YL)PYRROLIDIN-1-YL]-2-OXOETHYL}-N~2~-METHYL-L-ALANINAMIDE'>516</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:57:16 2009''
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gt9 OCA], [https://pdbe.org/3gt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gt9 RCSB], [https://www.ebi.ac.uk/pdbsum/3gt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gt9 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BIRC7_HUMAN BIRC7_HUMAN] Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.<ref>PMID:11084335</ref> <ref>PMID:16729033</ref> <ref>PMID:17294084</ref> <ref>PMID:18034418</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/3gt9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gt9 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Cohen F]]
 +
[[Category: Fairbrother WJ]]
 +
[[Category: Franklin MC]]

Current revision

Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic

PDB ID 3gt9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3gt9"
Personal tools