2pd4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2pd4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pd4, resolution 2.30&Aring;" /> '''Crystal Structure of...)
Current revision (09:00, 25 October 2023) (edit) (undo)
 
(17 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2pd4.gif|left|200px]]<br /><applet load="2pd4" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2pd4, resolution 2.30&Aring;" />
 
-
'''Crystal Structure of the Helicobacter pylori Enoyl-Acyl Carrier Protein Reductase in Complex with Hydroxydiphenyl Ether Compounds, Triclosan and Diclosan'''<br />
 
-
==About this Structure==
+
==Crystal Structure of the Helicobacter pylori Enoyl-Acyl Carrier Protein Reductase in Complex with Hydroxydiphenyl Ether Compounds, Triclosan and Diclosan==
-
2PD4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] with NAD and DCN as [http://en.wikipedia.org/wiki/ligands ligands]. This structure superseeds the now removed PDB entry 1JW7. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PD4 OCA].
+
<StructureSection load='2pd4' size='340' side='right'caption='[[2pd4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
+
== Structural highlights ==
-
[[Category: Helicobacter pylori]]
+
<table><tr><td colspan='2'>[[2pd4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jw7 1jw7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PD4 FirstGlance]. <br>
-
[[Category: Single protein]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
[[Category: Lee, H.H.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCN:DICLOSAN'>DCN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-
[[Category: Moon, J.H.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pd4 OCA], [https://pdbe.org/2pd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2pd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pd4 ProSAT]</span></td></tr>
-
[[Category: Suh, S.W.]]
+
</table>
-
[[Category: DCN]]
+
== Function ==
-
[[Category: NAD]]
+
[https://www.uniprot.org/uniprot/FABI_HELPY FABI_HELPY] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).
-
[[Category: antibacterial target]]
+
== Evolutionary Conservation ==
-
[[Category: enoyl-acp-reductase]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: fabi]]
+
Check<jmol>
-
[[Category: helicobacter pylori]]
+
<jmolCheckbox>
-
[[Category: type ii fatty acid biosynthesis]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pd/2pd4_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pd4 ConSurf].
 +
<div style="clear:both"></div>
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 13:30:05 2007''
+
==See Also==
 +
*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Helicobacter pylori]]
 +
[[Category: Large Structures]]
 +
[[Category: Lee HH]]
 +
[[Category: Moon JH]]
 +
[[Category: Suh SW]]

Current revision

Crystal Structure of the Helicobacter pylori Enoyl-Acyl Carrier Protein Reductase in Complex with Hydroxydiphenyl Ether Compounds, Triclosan and Diclosan

PDB ID 2pd4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2pd4"
Personal tools