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2ovs

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{{Seed}}
 
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[[Image:2ovs.png|left|200px]]
 
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==Crystal structure of a Type Three secretion System protein==
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The line below this paragraph, containing "STRUCTURE_2ovs", creates the "Structure Box" on the page.
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<StructureSection load='2ovs' size='340' side='right'caption='[[2ovs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ovs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OVS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2ovs| PDB=2ovs | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Orf10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ovs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovs OCA], [https://pdbe.org/2ovs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ovs RCSB], [https://www.ebi.ac.uk/pdbsum/2ovs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ovs ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Enterohemorrhagic Escherichia coli (EHEC) is a common cause of severe hemorrhagic colitis. EHEC's virulence is dependent upon a type III secretion system (TTSS) encoded by 41 genes. These genes are organized in several operons clustered in the locus of enterocyte effacement. Most of the locus of enterocyte effacement genes, including grlA and grlR, are positively regulated by Ler, and Ler expression is positively and negatively modulated by GrlA and GrlR, respectively. However, the molecular basis for the GrlA and GrlR activity is still elusive. We have determined the crystal structure of GrlR at 1.9 A resolution. It consists of a typical beta-barrel fold with eight beta-strands containing an internal hydrophobic cavity and a plug-like loop on one side of the barrel. Strong hydrophobic interactions between the two beta-barrels maintain the dimeric architecture of GrlR. Furthermore, a unique surface-exposed EDED (Glu-Asp-Glu-Asp) motif is identified to be critical for GrlA-GrlR interaction and for the repressive activity of GrlR. This study contributes a novel molecular insight into the mechanism of GrlR function.
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===Crystal strcuture of a Type Three secretion System protein===
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Structure of GrlR and the implication of its EDED motif in mediating the regulation of type III secretion system in EHEC.,Jobichen C, Li M, Yerushalmi G, Tan YW, Mok YK, Rosenshine I, Leung KY, Sivaraman J PLoS Pathog. 2007 May 18;3(5):e69. PMID:17511515<ref>PMID:17511515</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2OVS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVS OCA].
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<div class="pdbe-citations 2ovs" style="background-color:#fffaf0;"></div>
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[[Category: Escherichia coli]]
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== References ==
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[[Category: Jobichen, C.]]
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<references/>
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[[Category: Li, M.]]
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__TOC__
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[[Category: Sivaraman, J.]]
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</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Large Structures]]
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[[Category: Jobichen, C]]
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[[Category: Li, M]]
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[[Category: Sivaraman, J]]
[[Category: Gene regulation]]
[[Category: Gene regulation]]
[[Category: Global regulator protein type three secretion system]]
[[Category: Global regulator protein type three secretion system]]
[[Category: Ligand binding protein]]
[[Category: Ligand binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:24:34 2009''
 

Current revision

Crystal structure of a Type Three secretion System protein

PDB ID 2ovs

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