2p2j

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{{Seed}}
 
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[[Image:2p2j.png|left|200px]]
 
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==Acetyl-CoA Synthetase, K609A mutation==
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The line below this paragraph, containing "STRUCTURE_2p2j", creates the "Structure Box" on the page.
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<StructureSection load='2p2j' size='340' side='right'caption='[[2p2j]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p2j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P2J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PRX:ADENOSINE-5-MONOPHOSPHATE-PROPYL+ESTER'>PRX</scene></td></tr>
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{{STRUCTURE_2p2j| PDB=2p2j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p2j OCA], [https://pdbe.org/2p2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p2j RCSB], [https://www.ebi.ac.uk/pdbsum/2p2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p2j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACSA_SALTY ACSA_SALTY] Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.<ref>PMID:17497934</ref> Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis (By similarity).<ref>PMID:17497934</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p2/2p2j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p2j ConSurf].
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<div style="clear:both"></div>
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===Acetyl-CoA Synthetase, K609A mutation===
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==See Also==
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*[[Acetyl-CoA synthetase|Acetyl-CoA synthetase]]
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*[[Acetyl-CoA synthetase 3D structures|Acetyl-CoA synthetase 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_17497934}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 17497934 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_17497934}}
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[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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==About this Structure==
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[[Category: Gulick AM]]
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2P2J is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P2J OCA].
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[[Category: Reger AS]]
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==Reference==
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<ref group="xtra">PMID:17497934</ref><references group="xtra"/>
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[[Category: Acetate--CoA ligase]]
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Gulick, A M.]]
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[[Category: Reger, A S.]]
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[[Category: Acyl-coa ligase]]
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[[Category: Adenylate-forming enzyme]]
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[[Category: Domain alternation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:26:31 2009''
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Current revision

Acetyl-CoA Synthetase, K609A mutation

PDB ID 2p2j

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