2nwm

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{{Seed}}
 
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[[Image:2nwm.png|left|200px]]
 
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==Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin==
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The line below this paragraph, containing "STRUCTURE_2nwm", creates the "Structure Box" on the page.
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<StructureSection load='2nwm' size='340' side='right'caption='[[2nwm]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2nwm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NWM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nwm OCA], [https://pdbe.org/2nwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nwm RCSB], [https://www.ebi.ac.uk/pdbsum/2nwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nwm ProSAT]</span></td></tr>
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{{STRUCTURE_2nwm| PDB=2nwm | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VINEX_HUMAN VINEX_HUMAN] Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/2nwm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nwm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Solution structure of the first Src homology (SH) 3 domain of human vinexin (V_SH3_1) was determined using nuclear magnetic resonance (NMR) method and revealed that it was a canonical SH3 domain, which has a typical beta-beta-beta-beta-alpha-beta fold. Using chemical shift perturbation and surface plasmon resonance experiments, we studied the binding properties of the SH3 domain with two different peptides from vinculin hinge regions: P856 and P868. The observations illustrated slightly different affinities of the two peptides binding to V_SH3_1. The interaction between P868 and V_SH3_1 belonged to intermediate exchange with a modest binding affinity, while the interaction between P856 and V_SH3_1 had a low binding affinity. The structure and ligand-binding interface of V_SH3_1 provide a structural basis for the further functional study of this important molecule.
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===Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin===
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Solution structure of the first SH3 domain of human vinexin and its interaction with vinculin peptides.,Zhang J, Li X, Yao B, Shen W, Sun H, Xu C, Wu J, Shi Y Biochem Biophys Res Commun. 2007 Jun 15;357(4):931-7. Epub 2007 Apr 17. PMID:17467669<ref>PMID:17467669</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17467669}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2nwm" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17467669 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17467669}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2NWM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWM OCA].
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==Reference==
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<ref group="xtra">PMID:17467669</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Shi, Y.]]
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[[Category: Large Structures]]
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[[Category: Wu, J.]]
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[[Category: Shi Y]]
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[[Category: Yao, B.]]
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[[Category: Wu J]]
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[[Category: Zhang, J.]]
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[[Category: Yao B]]
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[[Category: Cell adhesion]]
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[[Category: Zhang J]]
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[[Category: Vinexin sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:43:42 2009''
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Current revision

Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin

PDB ID 2nwm

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