1n89

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{{Seed}}
 
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[[Image:1n89.png|left|200px]]
 
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==Solution structure of a liganded type 2 wheat non-specific Lipid Transfer Protein==
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The line below this paragraph, containing "STRUCTURE_1n89", creates the "Structure Box" on the page.
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<StructureSection load='1n89' size='340' side='right'caption='[[1n89]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_turgidum_subsp._durum Triticum turgidum subsp. durum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N89 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 9 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGM:1-MYRISTOYL-2-HYDROXY-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL)]'>PGM</scene></td></tr>
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{{STRUCTURE_1n89| PDB=1n89 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n89 OCA], [https://pdbe.org/1n89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n89 RCSB], [https://www.ebi.ac.uk/pdbsum/1n89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n89 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NLT2G_WHEAT NLT2G_WHEAT] Transfer lipids across membranes. May play a role in plant defense or in the biosynthesis of cuticle layers.<ref>PMID:11231292</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/1n89_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n89 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The refined structure of a wheat type 2 nonspecific lipid transfer protein (ns-LTP2) liganded with l-alpha-palmitoylphosphatidylglycerol has been determined by NMR. The (15)N-labeled protein was produced in Pichia pastoris. Physicochemical conditions and ligandation were intensively screened to obtain the best NMR spectra quality. This ns-LTP2 is a 67-residue globular protein with a diameter of about 30 A. The structure is composed of five helices forming a right superhelix. The protein presents an inner cavity, which has been measured at 341 A(3). All of the helices display hydrophobic side chains oriented toward the cavity. The phospholipid is found in this cavity. Its fatty acid chain is completely inserted in the protein, the l-alpha-palmitoylphosphatidylglycerol glycerol moiety being located on a positively charged pocket on the surface of the protein. The superhelix structure of the protein is coiled around the fatty acid chain. The overall structure shows similarities with ns-LTP1. Nevertheless, large three-dimensional structural discrepancies are observed for the H3 and H4 alpha-helices, the C-terminal region, and the last turn of the H2 helix. The lipid is orthogonal to the orientation observed in ns-LTP1. The volume of the hydrophobic cavity appears to be in the same range as the one of ns-LTP1, despite the fact that ns-LTP2 is shorter by 24 residues.
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===Solution structure of a liganded type 2 wheat non-specific Lipid Transfer Protein===
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Refined solution structure of a liganded type 2 wheat nonspecific lipid transfer protein.,Pons JL, de Lamotte F, Gautier MF, Delsuc MA J Biol Chem. 2003 Apr 18;278(16):14249-56. Epub 2003 Jan 13. PMID:12525478<ref>PMID:12525478</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_12525478}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1n89" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12525478 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12525478}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1N89 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Triticum_turgidum_subsp._durum Triticum turgidum subsp. durum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N89 OCA].
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==Reference==
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<ref group="xtra">PMID:12525478</ref><references group="xtra"/>
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[[Category: Triticum turgidum subsp. durum]]
[[Category: Triticum turgidum subsp. durum]]
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[[Category: Delsuc, M A.]]
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[[Category: Delsuc MA]]
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[[Category: Gautier, M F.]]
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[[Category: Gautier MF]]
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[[Category: Lamotte, F de.]]
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[[Category: Pons JL]]
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[[Category: Pons, J L.]]
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[[Category: De Lamotte F]]
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[[Category: Lipid transfer protein]]
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[[Category: Lipid transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 10:41:57 2009''
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Current revision

Solution structure of a liganded type 2 wheat non-specific Lipid Transfer Protein

PDB ID 1n89

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