2k13

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{{Seed}}
 
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[[Image:2k13.png|left|200px]]
 
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==Solution NMR Structure of the Leech Protein Saratin, a Novel Inhibitor of Haemostasis==
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The line below this paragraph, containing "STRUCTURE_2k13", creates the "Structure Box" on the page.
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<StructureSection load='2k13' size='340' side='right'caption='[[2k13]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haementeria_officinalis Haementeria officinalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K13 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k13 OCA], [https://pdbe.org/2k13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k13 RCSB], [https://www.ebi.ac.uk/pdbsum/2k13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k13 ProSAT]</span></td></tr>
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{{STRUCTURE_2k13| PDB=2k13 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D0VWW8_HAEOF D0VWW8_HAEOF]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The leech protein Saratin from Hirudo medicinalis prevents thrombocyte aggregation by interfering with the first binding step of the thrombocytes to collagen by binding to collagen. We solved the three-dimensional structure of the leech protein Saratin in solution and identified its collagen binding site by NMR titration experiments. The NMR structure of Saratin consists of one alpha-helix and a five-stranded beta-sheet arranged in the topology betabetaalphabetabetabeta. The C-terminal region, of about 20 amino acids in length, adopts no regular structure. NMR titration experiments with collagen peptides show that the collagen interaction of Saratin takes place in a kind of notch that is formed by the end of the alpha-helix and the beta-sheet. NMR data-driven docking experiments to collagen model peptides were used to elucidate the putative binding mode of Saratin and collagen. Mainly, parts of the first and the end of the fifth beta-strand, the loop connecting the alpha-helix and the third beta-strand, and a short part of the loop connecting the fourth and fifth beta-strand participate in binding.
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===Solution NMR Structure of the Leech Protein Saratin, a Novel Inhibitor of Haemostasis===
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Structure of the leech protein saratin and characterization of its binding to collagen.,Gronwald W, Bomke J, Maurer T, Domogalla B, Huber F, Schumann F, Kremer W, Fink F, Rysiok T, Frech M, Kalbitzer HR J Mol Biol. 2008 Sep 12;381(4):913-27. Epub 2008 Jun 18. PMID:18585393<ref>PMID:18585393</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2k13" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18585393 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18585393}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2K13 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Haementeria_officinalis Haementeria officinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K13 OCA].
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==Reference==
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<ref group="xtra">PMID:18585393</ref><references group="xtra"/>
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[[Category: Haementeria officinalis]]
[[Category: Haementeria officinalis]]
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[[Category: Bomke, J.]]
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[[Category: Large Structures]]
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[[Category: Frech, M.]]
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[[Category: Bomke J]]
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[[Category: Gronwald, W.]]
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[[Category: Frech M]]
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[[Category: Huber, F.]]
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[[Category: Gronwald W]]
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[[Category: Kalbitzer, H R.]]
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[[Category: Huber F]]
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[[Category: Kremer, W.]]
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[[Category: Kalbitzer HR]]
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[[Category: Maurer, T.]]
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[[Category: Kremer W]]
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[[Category: Schumann, F.]]
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[[Category: Maurer T]]
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[[Category: Wisotzki, B.]]
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[[Category: Schumann F]]
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[[Category: Collagen binding]]
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[[Category: Wisotzki B]]
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[[Category: Fold typical for pan domain]]
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[[Category: Mixed alpha/beta structure]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 10:44:53 2009''
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Current revision

Solution NMR Structure of the Leech Protein Saratin, a Novel Inhibitor of Haemostasis

PDB ID 2k13

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