2khn

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{{Seed}}
 
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[[Image:2khn.jpg|left|200px]]
 
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==NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.==
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The line below this paragraph, containing "STRUCTURE_2khn", creates the "Structure Box" on the page.
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<StructureSection load='2khn' size='340' side='right'caption='[[2khn]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [https://pdbe.org/2khn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [https://www.ebi.ac.uk/pdbsum/2khn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khn ProSAT], [https://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr>
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{{STRUCTURE_2khn| PDB=2khn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kh/2khn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2khn ConSurf].
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<div style="clear:both"></div>
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===NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.===
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==See Also==
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*[[Intersectin|Intersectin]]
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== References ==
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==About this Structure==
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<references/>
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2KHN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Everett, J K.]]
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[[Category: Acton TB]]
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[[Category: Foote, E L.]]
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[[Category: Everett JK]]
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[[Category: Garcia, E.]]
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[[Category: Foote EL]]
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[[Category: Ghosh, A.]]
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[[Category: Garcia E]]
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[[Category: Janjua, H.]]
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[[Category: Ghosh A]]
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[[Category: Mills, J L.]]
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[[Category: Janjua H]]
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[[Category: Montelione, G T.]]
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[[Category: Mills JL]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Shastry, R.]]
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[[Category: Shastry R]]
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[[Category: Szyperski, T.]]
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[[Category: Szyperski T]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Zhang, Q.]]
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[[Category: Zhang Q]]
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[[Category: Alternative splicing]]
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[[Category: Calcium]]
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[[Category: Cell junction]]
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[[Category: Cell projection]]
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[[Category: Coiled coil]]
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[[Category: Endocytosis]]
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[[Category: Gft nmr]]
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[[Category: High throughput]]
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[[Category: Human intersectin-1]]
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[[Category: Membrane]]
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[[Category: Nesgc]]
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[[Category: Nmr]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Phosphoprotein]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Synapse]]
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[[Category: Synaptosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 11:23:17 2009''
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Current revision

NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.

PDB ID 2khn

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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