3cxc

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{{Seed}}
 
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[[Image:3cxc.jpg|left|200px]]
 
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==The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui==
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The line below this paragraph, containing "STRUCTURE_3cxc", creates the "Structure Box" on the page.
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<StructureSection load='3cxc' size='340' side='right'caption='[[3cxc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cxc]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SLD:(3Z)-N-[(4E)-5-(4-{(5S)-5-[(ACETYLAMINO)METHYL]-2-OXO-1,3-OXAZOLIDIN-3-YL}-2-FLUOROPHENYL)PENT-4-EN-1-YL]-3-(4-METHYL-2,6-DIOXO-1,6-DIHYDROPYRIMIDIN-5(2H)-YLIDENE)PROPANAMIDE'>SLD</scene></td></tr>
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{{STRUCTURE_3cxc| PDB=3cxc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxc OCA], [https://pdbe.org/3cxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxc RCSB], [https://www.ebi.ac.uk/pdbsum/3cxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL2_HALMA RL2_HALMA] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_A]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella catarrahalis. The convergent synthesis of these new compounds is detailed.
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===The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui===
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Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.,Zhou J, Bhattacharjee A, Chen S, Chen Y, Duffy E, Farmer J, Goldberg J, Hanselmann R, Ippolito JA, Lou R, Orbin A, Oyelere A, Salvino J, Springer D, Tran J, Wang D, Wu Y, Johnson G Bioorg Med Chem Lett. 2008 Dec 1;18(23):6175-8. Epub 2008 Oct 7. PMID:18947996<ref>PMID:18947996</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3cxc" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18947996}}, adds the Publication Abstract to the page
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18947996 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18947996}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3CXC is a 30 chains structure of sequences from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXC OCA].
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==Reference==
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<ref group="xtra">PMID:18947996</ref><references group="xtra"/>
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[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
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[[Category: Duffy, E M.]]
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[[Category: Large Structures]]
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[[Category: Ippolito, J A.]]
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[[Category: Duffy EM]]
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[[Category: Kanyo, Z F.]]
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[[Category: Ippolito JA]]
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[[Category: Wang, D.]]
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[[Category: Kanyo ZF]]
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[[Category: 50s ribosomal subunit]]
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[[Category: Wang D]]
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[[Category: Oxazolidinone]]
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[[Category: Ribosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 30 09:57:35 2009''
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Current revision

The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui

PDB ID 3cxc

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OCA

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