3frp

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{{Seed}}
 
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[[Image:3frp.jpg|left|200px]]
 
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==Crystal Structure of Cobra Venom Factor, a Co-factor for C3- and C5 convertase CVFBb==
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The line below this paragraph, containing "STRUCTURE_3frp", creates the "Structure Box" on the page.
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<StructureSection load='3frp' size='340' side='right'caption='[[3frp]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3frp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FRP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3frp| PDB=3frp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3frp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3frp OCA], [https://pdbe.org/3frp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3frp RCSB], [https://www.ebi.ac.uk/pdbsum/3frp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3frp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VCO3_NAJKA VCO3_NAJKA] Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/3frp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3frp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cobra venom factor (CVF) is a functional analog of human complement component C3b, the active fragment of C3. Similar to C3b, in human and mammalian serum, CVF binds factor B, which is then cleaved by factor D, giving rise to the CVFBb complex that targets the same scissile bond in C3 as the authentic complement convertases C4bC2a and C3bBb. Unlike the latter, CVFBb is a stable complex and an efficient C5 convertase. We solved the crystal structure of CVF, isolated from Naja naja kouthia venom, at 2.6 A resolution. The CVF crystal structure, an intermediate between C3b and C3c, lacks the TED domain and has the CUB domain in an identical position to that seen in C3b. The similarly positioned CUB and slightly displaced C345c domains of CVF could play a vital role in the formation of C3 convertases by providing important primary binding sites for factor B.
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===Crystal Structure of Cobra Venom Factor, a Co-factor for C3- and C5 convertase CVFBb===
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The crystal structure of cobra venom factor, a cofactor for C3- and C5-convertase CVFBb.,Krishnan V, Ponnuraj K, Xu Y, Macon K, Volanakis JE, Narayana SV Structure. 2009 Apr 15;17(4):611-9. PMID:19368894<ref>PMID:19368894</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3frp" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19368894}}, adds the Publication Abstract to the page
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*[[Cobra venom factor|Cobra venom factor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19368894 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19368894}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3FRP is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FRP OCA].
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==Reference==
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<ref group="xtra">PMID:19368894</ref><references group="xtra"/>
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[[Category: Naja kaouthia]]
[[Category: Naja kaouthia]]
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[[Category: Krishnan, V.]]
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[[Category: Krishnan V]]
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[[Category: Narayana, S V.L.]]
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[[Category: Narayana SVL]]
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[[Category: Cobra venom factor]]
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[[Category: Complement alternate pathway]]
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[[Category: Complement c3 and c5 convertase cvfbb]]
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[[Category: Complement pathway]]
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[[Category: Complement protein]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase cofactor]]
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[[Category: Immune response]]
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[[Category: Inflammatory response]]
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[[Category: Innate immunity]]
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[[Category: Naja naja kouthia]]
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[[Category: Secreted]]
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[[Category: Thioester bond]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 30 10:06:20 2009''
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Current revision

Crystal Structure of Cobra Venom Factor, a Co-factor for C3- and C5 convertase CVFBb

PDB ID 3frp

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