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2sbt
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2sbt" size="450" color="white" frame="true" align="right" spinBox="true" caption="2sbt, resolution 2.8Å" /> '''A COMPARISON OF THE T...) |
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| - | [[Image:2sbt.gif|left|200px]]<br /><applet load="2sbt" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2sbt, resolution 2.8Å" /> | ||
| - | '''A COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SUBTILISIN BPN AND SUBTILISIN NOVO'''<br /> | ||
| - | == | + | ==A COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SUBTILISIN BPN AND SUBTILISIN NOVO== |
| - | + | <StructureSection load='2sbt' size='340' side='right'caption='[[2sbt]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2sbt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2SBT FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2sbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sbt OCA], [https://pdbe.org/2sbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2sbt RCSB], [https://www.ebi.ac.uk/pdbsum/2sbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2sbt ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SUBT_BACAM SUBT_BACAM] Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides. Has a high substrate specificity to fibrin.<ref>PMID:12524032</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sb/2sbt_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2sbt ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Subtilisin 3D structures|Subtilisin 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bacillus amyloliquefaciens]] | [[Category: Bacillus amyloliquefaciens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Drenth J]] | |
| - | [[Category: Drenth | + | [[Category: Hol WGJ]] |
| - | [[Category: Hol | + | [[Category: Jansonius JN]] |
| - | [[Category: Jansonius | + | [[Category: Koekoek R]] |
| - | [[Category: Koekoek | + | |
| - | + | ||
| - | + | ||
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Current revision
A COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SUBTILISIN BPN AND SUBTILISIN NOVO
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