3eoa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:47, 17 October 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3eoa.png|left|200px]]
 
-
<!--
+
==Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I==
-
The line below this paragraph, containing "STRUCTURE_3eoa", creates the "Structure Box" on the page.
+
<StructureSection load='3eoa' size='340' side='right'caption='[[3eoa]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3eoa]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EOA FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoa OCA], [https://pdbe.org/3eoa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eoa RCSB], [https://www.ebi.ac.uk/pdbsum/3eoa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eoa ProSAT]</span></td></tr>
-
{{STRUCTURE_3eoa| PDB=3eoa | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eoa_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eoa ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Lymphocyte function-associated antigen 1 (LFA-1) plays important roles in immune cell adhesion, trafficking, and activation and is a therapeutic target for the treatment of multiple autoimmune diseases. Efalizumab is one of the most efficacious antibody drugs for treating psoriasis, a very common skin disease, through inhibition of the binding of LFA-1 to the ligand intercellular adhesion molecule 1 (ICAM-1). We report here the crystal structures of the Efalizumab Fab alone and in complex with the LFA-1 alpha(L) I domain, which reveal the molecular mechanism of inhibition of LFA-1 by Efalizumab. The Fab binds with an epitope on the inserted (I) domain that is distinct from the ligand-binding site. Efalizumab binding blocks the binding of LFA-1 to ICAM-1 via steric hindrance between its light chain and ICAM-1 domain 2 and thus inhibits the activities of LFA-1. These results have important implications for the development of improved antibodies and new therapeutic strategies for the treatment of autoimmune diseases.
-
===Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I===
+
Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance.,Li S, Wang H, Peng B, Zhang M, Zhang D, Hou S, Guo Y, Ding J Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4349-54. Epub 2009 Mar 3. PMID:19258452<ref>PMID:19258452</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3eoa" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_19258452}}, adds the Publication Abstract to the page
+
*[[Integrin 3D structures|Integrin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 19258452 is the PubMed ID number.
+
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
-
-->
+
== References ==
-
{{ABSTRACT_PUBMED_19258452}}
+
<references/>
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
3EOA is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOA OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:19258452</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Ding, J.]]
+
[[Category: Large Structures]]
-
[[Category: Li, S.]]
+
[[Category: Ding J]]
-
[[Category: Alternative splicing]]
+
[[Category: Li S]]
-
[[Category: Antibody]]
+
-
[[Category: Calcium]]
+
-
[[Category: Cd11a]]
+
-
[[Category: Efalizumab]]
+
-
[[Category: Fab]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: I domain]]
+
-
[[Category: Immune system/cell adhesion complex]]
+
-
[[Category: Integrin]]
+
-
[[Category: Lfa-1]]
+
-
[[Category: Magnesium]]
+
-
[[Category: Membrane]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Receptor]]
+
-
[[Category: Transmembrane]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:10:23 2009''
+

Current revision

Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I

PDB ID 3eoa

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3eoa"
Personal tools