3fgh

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{{Seed}}
 
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[[Image:3fgh.png|left|200px]]
 
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==Human mitochondrial transcription factor A box B==
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The line below this paragraph, containing "STRUCTURE_3fgh", creates the "Structure Box" on the page.
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<StructureSection load='3fgh' size='340' side='right'caption='[[3fgh]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FGH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_3fgh| PDB=3fgh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fgh OCA], [https://pdbe.org/3fgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fgh RCSB], [https://www.ebi.ac.uk/pdbsum/3fgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fgh ProSAT]</span></td></tr>
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</table>
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===Human mitochondrial transcription factor A box B===
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== Function ==
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[https://www.uniprot.org/uniprot/TFAM_HUMAN TFAM_HUMAN] Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.<ref>PMID:1737790</ref> <ref>PMID:20410300</ref> <ref>PMID:19304746</ref> <ref>PMID:22037172</ref> <ref>PMID:22037171</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19304746}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19304746 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fg/3fgh_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19304746}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3FGH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FGH OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fgh ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:19304746</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Churchill, M E.A.]]
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[[Category: Large Structures]]
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[[Category: Gangelhoff, T A.]]
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[[Category: Churchill MEA]]
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[[Category: Mungalachetty, P.]]
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[[Category: Gangelhoff TA]]
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[[Category: Nix, J.]]
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[[Category: Mungalachetty P]]
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[[Category: Activator]]
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[[Category: Nix J]]
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[[Category: Dna-binding]]
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[[Category: Hmg domain]]
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[[Category: Mitochondrial transcription]]
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[[Category: Mitochondrion]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transit peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:17:00 2009''
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Current revision

Human mitochondrial transcription factor A box B

PDB ID 3fgh

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OCA

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