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3fpp

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{{Seed}}
 
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[[Image:3fpp.png|left|200px]]
 
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<!--
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==Crystal structure of E.coli MacA==
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The line below this paragraph, containing "STRUCTURE_3fpp", creates the "Structure Box" on the page.
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<StructureSection load='3fpp' size='340' side='right'caption='[[3fpp]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fpp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FPP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fpp OCA], [https://pdbe.org/3fpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fpp RCSB], [https://www.ebi.ac.uk/pdbsum/3fpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fpp ProSAT]</span></td></tr>
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{{STRUCTURE_3fpp| PDB=3fpp | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of E.coli MacA===
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[https://www.uniprot.org/uniprot/MACA_ECOLI MACA_ECOLI] Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, MacA binds tightly rough-core lipopolysaccharide (R-LPS), suggesting that the system could also transport R-LPS or a similar glycolipid.<ref>PMID:11544226</ref> <ref>PMID:17214741</ref> <ref>PMID:18955484</ref> <ref>PMID:21696464</ref> <ref>PMID:23974027</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_19254725}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 19254725 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/3fpp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_19254725}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fpp ConSurf].
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3FPP is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPP OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19254725</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Ha, N C.]]
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[[Category: Large Structures]]
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[[Category: Piao, S.]]
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[[Category: Ha N-C]]
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[[Category: Xu, Y.]]
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[[Category: Piao S]]
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[[Category: Yum, S.]]
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[[Category: Xu Y]]
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[[Category: Antibiotic resistance]]
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[[Category: Yum S]]
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[[Category: Cell inner membrane]]
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[[Category: Cell membrane]]
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[[Category: Drug efflux pump]]
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[[Category: Hexameric assembly]]
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[[Category: Membrane]]
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[[Category: Membrane fusion protein]]
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[[Category: Membrane protein]]
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[[Category: Periplasmic protein]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:23:53 2009''
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Current revision

Crystal structure of E.coli MacA

PDB ID 3fpp

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