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2k7h

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{{Seed}}
 
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[[Image:2k7h.jpg|left|200px]]
 
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==NMR solution structure of soybean allergen Gly m 4==
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The line below this paragraph, containing "STRUCTURE_2k7h", creates the "Structure Box" on the page.
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<StructureSection load='2k7h' size='340' side='right'caption='[[2k7h]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K7H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k7h OCA], [https://pdbe.org/2k7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k7h RCSB], [https://www.ebi.ac.uk/pdbsum/2k7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k7h ProSAT]</span></td></tr>
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{{STRUCTURE_2k7h| PDB=2k7h | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAM22_SOYBN SAM22_SOYBN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/2k7h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k7h ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In many cases, patients allergic to birch pollen also show allergic reactions after ingestion of certain fruits or vegetables. This observation is explained at the molecular level by cross-reactivity of IgE antibodies induced by sensitization to the major birch pollen allergen Bet v 1 with homologous food allergens. As IgE antibodies recognize conformational epitopes, a precise structural characterization of the allergens involved is necessary to understand cross-reactivity and thus to develop new methods of allergen-specific immunotherapy for allergic patients. Here, we report the three-dimensional solution structure of the soybean allergen Gly m 4, a member of the superfamily of Bet v 1 homologous proteins and a cross-reactant with IgE antibodies originally raised against Bet v 1 as shown by immunoblot inhibition and histamine release assays. Although the overall fold of Gly m 4 is very similar to that of Bet v 1, the three-dimensional structures of these proteins differ in detail. The Gly m 4 local structures that display those differences are also found in proteins from yellow lupine with known physiological function. The three-dimensional structure of Gly m 4 may thus shed some light on the physiological function of this subgroup of PR10 proteins (class 10 of pathogenesis-related proteins) and, in combination with immunological data, allow us to propose surface patches that might represent cross-reactive epitopes.
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===NMR solution structure of soybean allergen Gly m 4===
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Cross-reactivity of pollen and food allergens: soybean Gly m 4 is a member of the Bet v 1 superfamily and closely resembles yellow lupine proteins.,Berkner H, Neudecker P, Mittag D, Ballmer-Weber BK, Schweimer K, Vieths S, Rosch P Biosci Rep. 2009 Jun;29(3):183-92. PMID:18834331<ref>PMID:18834331</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18834331}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2k7h" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18834331 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18834331}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2K7H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7H OCA].
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==Reference==
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<ref group="xtra">PMID:18834331</ref><references group="xtra"/>
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[[Category: Glycine max]]
[[Category: Glycine max]]
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[[Category: Ballmer-Weber, B K.]]
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[[Category: Large Structures]]
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[[Category: Berkner, H.]]
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[[Category: Ballmer-Weber BK]]
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[[Category: Mittag, D.]]
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[[Category: Berkner H]]
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[[Category: Neudecker, P.]]
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[[Category: Mittag D]]
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[[Category: Roesch, P.]]
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[[Category: Neudecker P]]
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[[Category: Schweimer, K.]]
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[[Category: Roesch P]]
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[[Category: Vieths, S.]]
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[[Category: Schweimer K]]
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[[Category: Allergen]]
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[[Category: Vieths S]]
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[[Category: Allergen]]
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[[Category: Nmr]]
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[[Category: Pathogenesis-related protein]]
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[[Category: Plant defense]]
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[[Category: Protein]]
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[[Category: Soybean]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:34:23 2009''
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Current revision

NMR solution structure of soybean allergen Gly m 4

PDB ID 2k7h

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