2w2v

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{{Seed}}
 
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[[Image:2w2v.jpg|left|200px]]
 
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==Rac2 (G12V) in complex with GTPgS==
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The line below this paragraph, containing "STRUCTURE_2w2v", creates the "Structure Box" on the page.
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<StructureSection load='2w2v' size='340' side='right'caption='[[2w2v]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w2v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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{{STRUCTURE_2w2v| PDB=2w2v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2v OCA], [https://pdbe.org/2w2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2v RCSB], [https://www.ebi.ac.uk/pdbsum/2w2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2v ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN] Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome (NEUID) [MIM:[https://omim.org/entry/608203 608203].<ref>PMID:10758162</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.<ref>PMID:1660188</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w2v ConSurf].
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<div style="clear:both"></div>
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===RAC2 (G12V) IN COMPLEX WITH GTPGS===
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==See Also==
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*[[Rac 3D structures|Rac 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19394299 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19394299}}
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==About this Structure==
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2W2V is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2V OCA].
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==Reference==
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<ref group="xtra">PMID:19394299</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bunney, T D.]]
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[[Category: Large Structures]]
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[[Category: Opaleye, O.]]
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[[Category: Bunney TD]]
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[[Category: Pearl, L H.]]
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[[Category: Opaleye O]]
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[[Category: Roe, S M.]]
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[[Category: Pearl LH]]
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[[Category: Adp-ribosylation]]
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[[Category: Roe SM]]
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[[Category: Cytoplasm]]
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[[Category: Direct protein sequencing]]
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[[Category: Disease mutation]]
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[[Category: Gtp-binding]]
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[[Category: Lipoprotein]]
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[[Category: Methylation]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoinositide]]
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[[Category: Phospholipase c]]
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[[Category: Polymorphism]]
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[[Category: Prenylation]]
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[[Category: Rho]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:46:16 2009''
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Current revision

Rac2 (G12V) in complex with GTPgS

PDB ID 2w2v

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