3d8m

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{{Seed}}
 
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[[Image:3d8m.png|left|200px]]
 
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==Crystal structure of a chimeric receptor binding protein from lactococcal phages subspecies TP901-1 and p2==
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The line below this paragraph, containing "STRUCTURE_3d8m", creates the "Structure Box" on the page.
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<StructureSection load='3d8m' size='340' side='right'caption='[[3d8m]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d8m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_phage_TP901-1 Lactococcus phage TP901-1] and [https://en.wikipedia.org/wiki/Lactococcus_virus_P2 Lactococcus virus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D8M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d8m OCA], [https://pdbe.org/3d8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d8m RCSB], [https://www.ebi.ac.uk/pdbsum/3d8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d8m ProSAT]</span></td></tr>
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{{STRUCTURE_3d8m| PDB=3d8m | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9G096_9CAUD Q9G096_9CAUD]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/3d8m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d8m ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Lactococcus lactis, a gram-positive bacterium widely used by the dairy industry to manufacture cheeses, is subject to infection by a diverse population of virulent phages. We have previously determined the structures of three receptor binding proteins (RBPs) from lactococcal phages TP901-1, p2, and bIL170, each of them having a distinct host range. Virulent phages p2 and bIL170 are classified within the 936 group, while the temperate phage TP901-1 is a member of the genetically distinct P335 polythetic group. These RBPs comprise three domains: the N-terminal domain, binding to the virion particle; a beta-helical linker domain; and the C-terminal domain, bearing the receptor binding site used for host recognition. Here, we have designed, expressed, and determined the structure of an RBP chimera in which the N-terminal and linker RBP domains of phage TP901-1 (P335) are fused to the C-terminal RBP domain of phage p2 (936). This chimera exhibits a stable structure that closely resembles the parental structures, while a slight displacement of the linker made RBP domain adaptation efficient. The receptor binding site is structurally indistinguishable from that of native p2 RBP and binds glycerol with excellent affinity.
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===Crystal structure of a chimeric receptor binding protein from lactococcal phages subspecies TP901-1 and p2===
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Crystal structure of a chimeric receptor binding protein constructed from two lactococcal phages.,Siponen M, Spinelli S, Blangy S, Moineau S, Cambillau C, Campanacci V J Bacteriol. 2009 May;191(10):3220-5. Epub 2009 Mar 13. PMID:19286807<ref>PMID:19286807</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19286807}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3d8m" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19286807 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19286807}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Lactococcus phage TP901-1]]
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3D8M is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_phage_tp901-1,_lactococcus_phage_p2 Lactococcus phage tp901-1, lactococcus phage p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D8M OCA].
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[[Category: Lactococcus virus P2]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Blangy S]]
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<ref group="xtra">PMID:19286807</ref><references group="xtra"/>
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[[Category: Cambillau C]]
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[[Category: Lactococcus phage tp901-1, lactococcus phage p2]]
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[[Category: Campanacci V]]
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[[Category: Blangy, S.]]
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[[Category: Siponen MI]]
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[[Category: Cambillau, C.]]
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[[Category: Spinelli S]]
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[[Category: Campanacci, V.]]
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[[Category: Siponen, M I.]]
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[[Category: Spinelli, S.]]
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[[Category: Lactococcal phage p2]]
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[[Category: Lactococcal phage tp901-1]]
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[[Category: Receptor binding protein]]
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[[Category: Virus/viral protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:50:15 2009''
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Current revision

Crystal structure of a chimeric receptor binding protein from lactococcal phages subspecies TP901-1 and p2

PDB ID 3d8m

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