3gja

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{{Seed}}
 
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[[Image:3gja.png|left|200px]]
 
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==CytC3==
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The line below this paragraph, containing "STRUCTURE_3gja", creates the "Structure Box" on the page.
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<StructureSection load='3gja' size='340' side='right'caption='[[3gja]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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{{STRUCTURE_3gja| PDB=3gja | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gja OCA], [https://pdbe.org/3gja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gja RCSB], [https://www.ebi.ac.uk/pdbsum/3gja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gja ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D0VX22_STRSQ D0VX22_STRSQ]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/3gja_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gja ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CytC3, a member of the recently discovered class of nonheme Fe(II) and alpha-ketoglutarate (alphaKG)-dependent halogenases, catalyzes the double chlorination of L-2-aminobutyric acid (Aba) to produce a known Streptomyces antibiotic, gamma,gamma-dichloroaminobutyrate. Unlike the majority of the Fe(II)-alphaKG-dependent enzymes that catalyze hydroxylation reactions, halogenases catalyze a transfer of halides. To examine the important enzymatic features that discriminate between chlorination and hydroxylation, the crystal structures of CytC3 both with and without alphaKG/Fe(II) have been solved to 2.2 A resolution. These structures capture CytC3 in an open active site conformation, in which no chloride is bound to iron. Comparison of the open conformation of CytC3 with the closed conformation of another nonheme iron halogenase, SyrB2, suggests two important criteria for creating an enzyme-bound Fe-Cl catalyst: (1) the presence of a hydrogen-bonding network between the chloride and surrounding residues, and (2) the presence of a hydrophobic pocket in which the chloride resides.
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===CytC3===
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Structural analysis of an open active site conformation of nonheme iron halogenase CytC3.,Wong C, Fujimori DG, Walsh CT, Drennan CL J Am Chem Soc. 2009 Apr 8;131(13):4872-9. PMID:19281171<ref>PMID:19281171</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19281171}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3gja" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19281171 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19281171}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3GJA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJA OCA].
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[[Category: Streptomyces sp]]
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[[Category: Drennan CL]]
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==Reference==
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[[Category: Wong C]]
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<ref group="xtra">PMID:19281171</ref><references group="xtra"/>
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[[Category: Streptomyces sp.]]
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[[Category: Drennan, C L.]]
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[[Category: Wong, C.]]
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[[Category: Beta barrel]]
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[[Category: Biosynthetic protein]]
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[[Category: Cytc3]]
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[[Category: Halogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:56:54 2009''
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Current revision

CytC3

PDB ID 3gja

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