3h6o

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{{Seed}}
 
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[[Image:3h6o.jpg|left|200px]]
 
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==Activator-Bound Structure of Human Pyruvate Kinase M2==
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The line below this paragraph, containing "STRUCTURE_3h6o", creates the "Structure Box" on the page.
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<StructureSection load='3h6o' size='340' side='right'caption='[[3h6o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3h6o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H6O FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D8G:6-(2-FLUOROBENZYL)-2,4-DIMETHYL-4,6-DIHYDRO-5H-THIENO[2,3 4,5]PYRROLO[2,3-D]PYRIDAZIN-5-ONE'>D8G</scene>, <scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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{{STRUCTURE_3h6o| PDB=3h6o | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h6o OCA], [https://pdbe.org/3h6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h6o RCSB], [https://www.ebi.ac.uk/pdbsum/3h6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h6o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/3h6o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h6o ConSurf].
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<div style="clear:both"></div>
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===Activator-Bound Structure of Human Pyruvate Kinase M2===
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==See Also==
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*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3H6O is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H6O OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pyruvate kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Auld, D.]]
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[[Category: Auld D]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Boxer, M.]]
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[[Category: Boxer M]]
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[[Category: Dimov, S.]]
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[[Category: Dimov S]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Hong, B.]]
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[[Category: Hong B]]
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[[Category: Inglese, J.]]
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[[Category: Inglese J]]
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[[Category: Jianq, J K.]]
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[[Category: Jianq J-K]]
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[[Category: Min, S.]]
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[[Category: Min S]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Skoumbourdis A]]
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[[Category: Skoumbourdis, A.]]
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[[Category: Southall N]]
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[[Category: Southall, N.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Thomas C]]
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[[Category: Thomas, C.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Acetylation]]
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[[Category: Activator]]
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[[Category: Allosteric enzyme]]
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[[Category: Alternative splicing]]
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[[Category: Glycolysis]]
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[[Category: Kinase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Pyruvate]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 11:36:48 2009''
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Current revision

Activator-Bound Structure of Human Pyruvate Kinase M2

PDB ID 3h6o

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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