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3h87

From Proteopedia

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[[Image:3h87.jpg|left|200px]]
 
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==Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis==
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The line below this paragraph, containing "STRUCTURE_3h87", creates the "Structure Box" on the page.
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<StructureSection load='3h87' size='340' side='right'caption='[[3h87]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3h87]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H87 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3h87| PDB=3h87 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h87 OCA], [https://pdbe.org/3h87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h87 RCSB], [https://www.ebi.ac.uk/pdbsum/3h87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h87 ProSAT], [https://www.topsan.org/Proteins/ISFI/3h87 TOPSAN]</span></td></tr>
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</table>
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===Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis===
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== Function ==
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[https://www.uniprot.org/uniprot/VAPC2_MYCTU VAPC2_MYCTU] Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in M.smegmatis inhibits translation, growth and colony formation. All its toxic effects are neutralized by coexpression with cognate antitoxin VapB2.<ref>PMID:20011113</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3H87 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H87 OCA].
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Check<jmol>
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[[Category: Mycobacterium tuberculosis]]
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<jmolCheckbox>
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[[Category: Cascio, D.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h87_consurf.spt"</scriptWhenChecked>
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[[Category: Eisenberg, D.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: ISFI, Integrated Center for Structure and Function Innovation.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Min, A.]]
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</jmolCheckbox>
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[[Category: Sawaya, M R.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h87 ConSurf].
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[[Category: Integrated center for structure and function innovation]]
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<div style="clear:both"></div>
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[[Category: Isfi]]
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== References ==
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[[Category: Protein structure initiative]]
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<references/>
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[[Category: Psi-2]]
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__TOC__
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[[Category: Rhh motif]]
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</StructureSection>
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[[Category: Structural genomic]]
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[[Category: Large Structures]]
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[[Category: Toxin antitoxin complex]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Toxin/antitoxin complex]]
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[[Category: Cascio D]]
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[[Category: Tuberculosis]]
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[[Category: Eisenberg D]]
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[[Category: Min A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 11:37:28 2009''
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[[Category: Sawaya MR]]

Current revision

Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis

PDB ID 3h87

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