This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2tss

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2tss" size="450" color="white" frame="true" align="right" spinBox="true" caption="2tss, resolution 2.05&Aring;" /> '''TOXIC SHOCK SYNDROME...)
Current revision (09:24, 21 February 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2tss.gif|left|200px]]<br /><applet load="2tss" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2tss, resolution 2.05&Aring;" />
 
-
'''TOXIC SHOCK SYNDROME TOXIN-1 FROM STAPHYLOCOCCUS AUREUS: ORTHORHOMBICC222(1) CRYSTAL FORM'''<br />
 
-
==Overview==
+
==TOXIC SHOCK SYNDROME TOXIN-1 FROM STAPHYLOCOCCUS AUREUS: ORTHORHOMBICC222(1) CRYSTAL FORM==
-
The structure of toxic shock syndrome toxin-1 (TSST-1), the causative, agent in toxic shock syndrome, has been determined in three crystal forms., The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between, two symmetry-related molecules. Although not required for biological, activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very, low concentrations. In addition, the structure of the tetramutant TSST-1H, [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify, endotoxin shock, has been determined and refined in a fourth crystal form, (R-factor = 0.173 to 1.9 A resolution).
+
<StructureSection load='2tss' size='340' side='right'caption='[[2tss]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[2tss]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tss 1tss]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TSS FirstGlance]. <br>
-
2TSS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. This structure superseeds the now removed PDB entry 1TSS. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2TSS OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2tss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tss OCA], [https://pdbe.org/2tss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2tss RCSB], [https://www.ebi.ac.uk/pdbsum/2tss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2tss ProSAT]</span></td></tr>
-
==Reference==
+
</table>
-
Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci. 1997 Jun;6(6):1220-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9194182 9194182]
+
== Function ==
-
[[Category: Single protein]]
+
[https://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU] Responsible for the symptoms of toxic shock syndrome.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ts/2tss_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2tss ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
-
[[Category: Cook, W.J.]]
+
[[Category: Cook WJ]]
-
[[Category: Dinges, M.M.]]
+
[[Category: Dinges MM]]
-
[[Category: Earhart, C.A.]]
+
[[Category: Earhart CA]]
-
[[Category: Mitchell, D.T.]]
+
[[Category: Mitchell DT]]
-
[[Category: Ohlendorf, D.H.]]
+
[[Category: Ohlendorf DH]]
-
[[Category: Prasad, G.S.]]
+
[[Category: Prasad GS]]
-
[[Category: Radhakrishnan, R.]]
+
[[Category: Radhakrishnan R]]
-
[[Category: Schlivert, P.M.]]
+
[[Category: Schlivert PM]]
-
[[Category: signal]]
+
-
[[Category: superantigen]]
+
-
[[Category: toxin]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 14:06:52 2007''
+

Current revision

TOXIC SHOCK SYNDROME TOXIN-1 FROM STAPHYLOCOCCUS AUREUS: ORTHORHOMBICC222(1) CRYSTAL FORM

PDB ID 2tss

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2tss"
Personal tools