1v5s
From Proteopedia
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- | {{Seed}} | ||
- | [[Image:1v5s.png|left|200px]] | ||
- | < | + | ==Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3== |
- | + | <StructureSection load='1v5s' size='340' side='right'caption='[[1v5s]]' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[1v5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V5S FirstGlance]. <br> | |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
- | --> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5s OCA], [https://pdbe.org/1v5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v5s RCSB], [https://www.ebi.ac.uk/pdbsum/1v5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v5s ProSAT], [https://www.topsan.org/Proteins/RSGI/1v5s TOPSAN]</span></td></tr> |
- | + | </table> | |
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/MARK3_MOUSE MARK3_MOUSE] Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (By similarity). | ||
+ | == Evolutionary Conservation == | ||
+ | [[Image:Consurf_key_small.gif|200px|right]] | ||
+ | Check<jmol> | ||
+ | <jmolCheckbox> | ||
+ | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/1v5s_consurf.spt"</scriptWhenChecked> | ||
+ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
+ | <text>to colour the structure by Evolutionary Conservation</text> | ||
+ | </jmolCheckbox> | ||
+ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v5s ConSurf]. | ||
+ | <div style="clear:both"></div> | ||
- | == | + | ==See Also== |
- | + | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |
- | + | __TOC__ | |
- | + | </StructureSection> | |
- | + | [[Category: Large Structures]] | |
- | [[Category: | + | |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
- | [[Category: Inoue | + | [[Category: Inoue M]] |
- | [[Category: Kigawa | + | [[Category: Kigawa T]] |
- | [[Category: Koshiba | + | [[Category: Koshiba S]] |
- | + | [[Category: Tochio N]] | |
- | [[Category: Tochio | + | [[Category: Yokoyama S]] |
- | [[Category: Yokoyama | + | |
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Current revision
Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3
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Categories: Large Structures | Mus musculus | Inoue M | Kigawa T | Koshiba S | Tochio N | Yokoyama S