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2kdp

From Proteopedia

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{{Seed}}
 
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[[Image:2kdp.png|left|200px]]
 
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<!--
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==Solution Structure of the SAP30 zinc finger motif==
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The line below this paragraph, containing "STRUCTURE_2kdp", creates the "Structure Box" on the page.
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<StructureSection load='2kdp' size='340' side='right'caption='[[2kdp]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KDP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2kdp| PDB=2kdp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdp OCA], [https://pdbe.org/2kdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kdp RCSB], [https://www.ebi.ac.uk/pdbsum/2kdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kdp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAP30_HUMAN SAP30_HUMAN] Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.<ref>PMID:9651585</ref> [UniProtKB:O88574]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kdp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kdp ConSurf].
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<div style="clear:both"></div>
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===Solution Structure of the SAP30 zinc finger motif===
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19223330}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19223330 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_19223330}}
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==About this Structure==
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2KDP is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDP OCA].
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==Reference==
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<ref group="xtra">PMID:19223330</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: He, Y.]]
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[[Category: Large Structures]]
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[[Category: Imhoff, R.]]
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[[Category: He Y]]
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[[Category: Radhakrishnan, I.]]
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[[Category: Imhoff R]]
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[[Category: Sahu, A.]]
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[[Category: Radhakrishnan I]]
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[[Category: Nucleic acid interaction]]
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[[Category: Sahu A]]
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[[Category: Nucleus]]
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[[Category: Repressor]]
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[[Category: Sap30]]
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[[Category: Sin3]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc finger motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 09:05:20 2009''
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Current revision

Solution Structure of the SAP30 zinc finger motif

PDB ID 2kdp

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