2dix

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:41, 29 May 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2dix.png|left|200px]]
 
-
<!--
+
==Solution structure of the DSRM domain of Protein activator of the interferon-induced protein kinase==
-
The line below this paragraph, containing "STRUCTURE_2dix", creates the "Structure Box" on the page.
+
<StructureSection load='2dix' size='340' side='right'caption='[[2dix]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2dix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DIX FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dix OCA], [https://pdbe.org/2dix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dix RCSB], [https://www.ebi.ac.uk/pdbsum/2dix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dix ProSAT], [https://www.topsan.org/Proteins/RSGI/2dix TOPSAN]</span></td></tr>
-
{{STRUCTURE_2dix| PDB=2dix | SCENE= }}
+
</table>
-
 
+
== Disease ==
-
===Solution structure of the DSRM domain of Protein activator of the interferon-induced protein kinase===
+
[https://www.uniprot.org/uniprot/PRKRA_HUMAN PRKRA_HUMAN] Defects in PRKRA are the cause of dystonia type 16 (DYT16) [MIM:[https://omim.org/entry/612067 612067]. DYT16 is an early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features.<ref>PMID:18243799</ref> <ref>PMID:18420150</ref>
-
 
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/PRKRA_HUMAN PRKRA_HUMAN] Activates EIF2AK2/PKR in the absence of double stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1.<ref>PMID:9687506</ref> <ref>PMID:10336432</ref> <ref>PMID:11238927</ref> <ref>PMID:16424907</ref> <ref>PMID:16982605</ref> <ref>PMID:17452327</ref>
-
==About this Structure==
+
== Evolutionary Conservation ==
-
2DIX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIX OCA].
+
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2dix_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dix ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Dang, W.]]
+
[[Category: Large Structures]]
-
[[Category: Inoue, M.]]
+
[[Category: Dang W]]
-
[[Category: Kigawa, T.]]
+
[[Category: Inoue M]]
-
[[Category: Muto, Y.]]
+
[[Category: Kigawa T]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Muto Y]]
-
[[Category: Shirouzu, M.]]
+
[[Category: Shirouzu M]]
-
[[Category: Terada, T.]]
+
[[Category: Terada T]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yokoyama S]]
-
[[Category: Dsrm domain]]
+
-
[[Category: Hypothetical protein prkra]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nmr]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rna binding protein]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structure genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 09:41:50 2009''
+

Current revision

Solution structure of the DSRM domain of Protein activator of the interferon-induced protein kinase

PDB ID 2dix

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dix"
Personal tools