1x6e

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{{Seed}}
 
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[[Image:1x6e.png|left|200px]]
 
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==Solution structures of the C2H2 type zinc finger domain of human Zinc finger protein 24==
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The line below this paragraph, containing "STRUCTURE_1x6e", creates the "Structure Box" on the page.
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<StructureSection load='1x6e' size='340' side='right'caption='[[1x6e]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1x6e| PDB=1x6e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6e OCA], [https://pdbe.org/1x6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6e RCSB], [https://www.ebi.ac.uk/pdbsum/1x6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6e ProSAT], [https://www.topsan.org/Proteins/RSGI/1x6e TOPSAN]</span></td></tr>
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</table>
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===Solution structures of the C2H2 type zinc finger domain of human Zinc finger protein 24===
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== Function ==
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[https://www.uniprot.org/uniprot/ZNF24_HUMAN ZNF24_HUMAN] Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.<ref>PMID:10585455</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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1X6E is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6E OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/1x6e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x6e ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Koshiba S]]
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[[Category: Sato, M.]]
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[[Category: Sato M]]
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[[Category: Tomizawa, T.]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Dna binding protein]]
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[[Category: Kox17]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Zinc finger]]
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[[Category: Znf191]]
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[[Category: Znf24]]
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[[Category: Zscan3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 09:46:35 2009''
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Current revision

Solution structures of the C2H2 type zinc finger domain of human Zinc finger protein 24

PDB ID 1x6e

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