1mog

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(New page: 200px<br /><applet load="1mog" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mog, resolution 1.70&Aring;" /> '''Crystal structure of...)
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[[Image:1mog.gif|left|200px]]<br /><applet load="1mog" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1mog, resolution 1.70&Aring;" />
 
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'''Crystal structure of H. salinarum dodecin'''<br />
 
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==Overview==
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==Crystal structure of H. salinarum dodecin==
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A novel, 68 amino acid long flavoprotein called dodecin has been, discovered in the proteome of Halobacterium salinarum by inverse, structural genomics. The 1.7 A crystal structure of this protein shows a, dodecameric, hollow sphere-like arrangement of the protein subunits., Unlike other known flavoproteins, which bind only monomeric flavin, cofactors, the structure of the dodecin oligomer comprises six riboflavin, dimers. The dimerization of these riboflavins along the re-faces is, mediated by aromatic, antiparallel pi staggering of their isoalloxazine, moieties. A unique aromatic tetrade is formed by further sandwiching of, the riboflavin dimers between the indole groups of two symmetry-related, Trp36s. So far, the dodecins represent the smallest known flavoproteins., Based on the structure and the wide spread occurrences in pathogenic and, soil eubacteria, a function in flavin storage or protection against, radical or oxygenic stress is suggested for the dodecins.
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<StructureSection load='1mog' size='340' side='right'caption='[[1mog]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1mog]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MOG FirstGlance]. <br>
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1MOG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum] with MG, NA, CL and RBF as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MOG OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mog OCA], [https://pdbe.org/1mog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mog RCSB], [https://www.ebi.ac.uk/pdbsum/1mog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mog ProSAT]</span></td></tr>
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Crystal structure of halophilic dodecin: a novel, dodecameric flavin binding protein from Halobacterium salinarum., Bieger B, Essen LO, Oesterhelt D, Structure. 2003 Apr;11(4):375-85. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12679016 12679016]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9HPW4_HALSA Q9HPW4_HALSA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mo/1mog_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mog ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Halobacterium salinarum]]
[[Category: Halobacterium salinarum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bieger, B.]]
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[[Category: Bieger B]]
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[[Category: Essen, L.O.]]
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[[Category: Essen L-O]]
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[[Category: Oesterhelt, D.]]
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[[Category: Oesterhelt D]]
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[[Category: CL]]
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[[Category: MG]]
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[[Category: NA]]
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[[Category: RBF]]
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[[Category: 23-symmetric dodecamer]]
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[[Category: binding site for dimerized riboflavin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 21:44:43 2007''
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Current revision

Crystal structure of H. salinarum dodecin

PDB ID 1mog

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